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Glen research/3'-dC-CPG/1kit/20-2164-41M

Technical Documents
Description
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Technical Documents

Safety Data Sheet

Glen Report 8.14: 3"-Terminators

Description

Cellular DNA and RNA are made up of ribo- and 2"-deoxyribonucleic acids linked together via 3"-5" phosphodiester linkages and by far comprise the bulk of polynucleic acids found in cells. Much less common are oligonucleotides which have 2"-5" linkages. However, a unique feature of 2"-5" linked oligonucleotides is their ability to bind selectively to complementary RNA. These features suggest a number of interesting uses for 2"-5" linked oligos such as their use as RNA specific probes or in antisense oligos. Recently, oligos have been synthesized using 3"-deoxy-2"-phosphoramidites and 2"-deoxy-3"-phosphoramidites to produce chimeras with 2"-5" linked ends and 3"-5" linked central regions. It was found that 2"-5" phosphorothioate oligos: 1) bind selectively to complementary RNA with the same affinity as phosphodiester oligos; 2) exhibit much less nonspecific binding to cellular proteins; 3) do not activate RNase H. A 3"-deoxynucleoside at the 3"-terminus of an otherwise normal oligonucleotide effectively blocks polymerase extension.

Details

Usage

  • Coupling: This support should be used in a manner identical to normal protected nucleoside support since it contains the DMT group.
  • Deprotection: Deprotect using the protocol required by the nucleobases. Note: Deprotection in AMA (50:50 Ammonium hydroxide/MethylAmine) may result in about 5% N4-methyl-dC side product at the modification site.
Specifications
StorageControlled room temperature or lower, dry

Related Products

3'-dA-CE Phosphoramidite
3"-dA-CE PhosphoramiditeCatalog #: 10-1004
3'-dC-CE Phosphoramidite
3"-dC-CE PhosphoramiditeCatalog #: 10-1064
3'-dG-CE Phosphoramidite
3"-dG-CE PhosphoramiditeCatalog #: 10-1074
3'-dT-CE Phosphoramidite
3"-dT-CE PhosphoramiditeCatalog #: 10-1084
3'-dA-CPG
3"-dA-CPGCatalog #: 20-2004
3'-dG-CPG
3"-dG-CPGCatalog #: 20-2074
3'-dT-CPG
3"-dT-CPGCatalog #: 20-2084
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