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IBL/CD44var (v5) ELISA/BE59241/

Kitsize12x8
MethodELISA
Incubationtime1x3h,1x10min
Standardrange0.32-10ng/mL
Specimen/Volumes20µLserum,plasma,cellculturesupernatantetal.
Substrate/isotopeTMB450nm
RegulatoryStatus:Forresearchuseonly
Detailsfor: CD44var(v5)ELISA
CD44isapolymorphicglycoproteinwhichparticipatesinawidevarietyofcell-cellorcell-matrixinteractionsincludinglymphocytehoming,establishmentofBandTcellimmuneresponses,tumormetastasisformationandinflammation.
ThreeisoformcategoriesoftheCD44moleculehavebeenidentified:
1)apredominant80-90kDacategory,theso-calledstandardformnamedCD44std,
2)anintermediatesizecategoryof110-160kDaand
3)acategorywhichincludesverylargeisoformsof250kDacovalentlymodifiedbytheadditionofchondroitinsulfate.

ThisCD44-familyoftransmembranereceptormoleculesisderivedfromasinglegenelocatedonchromosome11.AlternativesplicingofthemRNAgivesrisetothedifferentisoforms,containinginsertsofvaryingsizesintheextracellulardomainofthemolecule(exonsv2-v10).IncontrasttostandardCD44(CD44std)whichisalmostubiquitouslyexpressed,thevarietyofCD44isoforms(CD44var)haveamuchmorerestricteddistribution,e.g.,onkeratinocytes(exonsv3-v10),epithelialcells(exonsv(-v10),activatedlymphocytesandmacrophages(exonv6).
AsplicevariantofCD44(exonsv4-v7)confersmetastaticbehaviorinaratcarcinomamodel;aberrantexpressionofsplicevariantshasbeendetectedonavarietyofhumantumorcelllinesaswellasprimaryandmetastatichumantumors,includinglymphomas,carcinomas(colon,thyroid,mamma,bladder),andgliomas.
DetectionofabnormalregulationofCD44splicingthuscouldbehelpfulincancerdiagnosisanddiseaseevaluation.
ThesCD44var(v5)ELISAdetectsallcirculatingCD44isoformscomprisingthesCD44var(v5)sequences.DeterminationofsCD44var(v5)willprovidemoredetailedinsightintodifferentpathologicalmodificationsduringcancerandotherdiseases.

Synonyms:VFF-8PhagocyticglycoproteinI,Hermesantigen
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.
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