Overview:
BRAFisamemberoftheRAFfamilythatisactivatedbymembersoftheRasfamilyupongrowthfactor-inducedstimulation.ActiveRascaninduceheterodimerizationofcRafandBRAFandthismayexplaintheobservedcooperativityofcRafandBRafincellsrespondingtogrowthfactorsignals(1).ActivatingmutationsintheBRAFgenearepresentinalargepercentageofhumanmalignantmelanomasandinaproportionofcoloncancers.Thevastmajorityofthesemutationsresultinavalinetoglutamicacidchangeatresidue599withintheactivationsegmentofB-RAF(2).
GeneAliases:
BRAF1,RAFB1,B-raf1,MGC126806,MGC138284
GenbankNumber:
NM_004333
References:
1.Weber,CK.etal:ActiveRasinducesheterodimerizationofcRafandBRaf.CancerRes.2001May1;61(9):3595-8.2.Mercer,KE.etal:Rafproteinsandcancer:B-Rafisidentifiedasamutationaltarget.BiochimBiophysActa.2003Jun5;1653(1):25-40.
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