Avanti Polar Lipids/16:0 Cyclic LPA / 857323/1 x 10mg

Products:

Cyclicphosphatidicacid(cPA)isanaturallyoccurringanalogofthegrowthfactor-likephospholipidmediator,lysophosphatidicacid(LPA).Thesn-2hydroxygroupofCPAformsa5-memberedringwiththesn-3phosphate.cPAaffectsnumerouscellularfunctions,includinganti-mitogenicregulationofthecellcycle¹,inductionofstressfiberformation²,inhibitionoftumorcellinvasionandmetastasis³,andregulationofdifferentiationandsurvivalofneuronalcells⁴.Interestingly,manyofthesecellularresponsescausedbycPAopposethoseofLPAdespitetheactivationofapparentlyoverlappingreceptorpopulations.

 

YoucanfindadditionalinformationoncPAatthefollowinglink:
 
LIPIDMAPSLipidomicsGateway

 

1.Murakami-Murofushi,K.,Kaji,K.,Kano,K.,Fukuda,M.,Shioda,M.,andMurofushi,H.(1993)Inhibitionofcellproliferationbyauniquelysophosphatidicacid,PHYLPA,isolatedfromPhysarumpolycephalum:signalingeventsofantiproliferativeactionbyPHYLPA.CellStruct.Funct.18:363–370.

 

2.Fischer,D.L.,Liliom,K.,Guo,H.,Nusser,N.,Virag,T.,Murakami-Murofushi,K.,Kobayashi,S.,Erickson,J.P.,Sun,G.,Miller,D.D.,andTigyi,G.(1998)Naturallyoccurringanalogsoflysophosphatidicacidelicitdifferentcellularresponsesthroughselectiveactivationofmultiplereceptorsubtypes. Mol.Pharmacol.54:979–988.

 

3.Mukai,M.,Imamura,F.,Ayaki,M.,Shinkai,K.,Iwasaki,T.,Murakami-Murofushi,K.,Murofushi,H.,Kobayashi,S.,Yamamoto,T.,Nakamura,H.,andAkedo,H.(1999)Inhibitionoftumorinvasionandmetastasisbyanovellysophosphatidicacid(cyclicLPA).Int.J.Cancer81:918–922.

 

4.Fujiwara,Y.,Sebok,A.,Meakin,S.,Kobayashi,T.,Murakami-Murofushi,K.,andTigyi,G.(2003)Cyclicphosphatidicacidelicitsneurotrophin-likeactionsinembryonichippocampalneurons.J.NeuRochem.87:1272–1283.

Data:

MolecularFormula

C₁₉H₄₀NO₆P

PercentComposition

C55.73%,H9.85%,N3.42%,O23.44%,P7.56%

Purity

>99%

StABIlity

1Years

Storage

-20°C

CASNumber

799268-71-6
CASRegistryNumberisaRegisteredTrademarkoftheAmericanChemicalSociety

MolecularWeight

409.498

ExactMass

409.259

Synonyms

1-hexadecanoyl-sn-glycero-2,3-cyclic-phosphate(ammoniumsalt)

cPA

cLPA