Description: Recombinant monoclonal antibody to GM-CSF. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the EBV transformed human B cell clone GCC21. This antibody was created using our proprietary Fc Silent™ engineered Fc domain containing key point mutations that abrogate binding to Fc gamma receptors. Species and Isotype: Human IgG1, Fc Silent™, kappa Clone Number: GCC21 UniProt Accession Number of Target Protein: Published Application(s): NTRL; Biacore; ELISA Published Species Reactivity: Human Immunogen: Antibody generated by sequencing of memory B-cells obtained from human patients suffering from chronic autoimmune pulmonary alveolar proteinosis. Specificity: This antibody binds to human GM-CSF at a site distinct to clone GCA43. Application Notes: This antibody binds to human GM-CSF and has neutralizing activity. Antibody First Published in: Piccoli et al. Neutralization and clearance of GM-CSF by autoantibodies in pulmonary alveolar proteinosis Nat Commun. 2015 Jun 16;6:7375 PMID:26077231 Note on publication: Describes the generation and characterization of this antibody.Product FormPurification: Protein A affinity purified Supplied in: PBS with preservative (0.02% Proclin 300) Storage Recommendation: Store at 4°C for up to 3 months. For longer term storage aliquot into small volumes and store at -20°C Concentration: See vial label.
Important note This product is for research use only. It is not intended for use in therapeutic or diagnosticprocedures for humans or animals.
