出版应用/物种/样本/稀释参考文献免疫印迹; 小鼠; 1:800; 图5aHuang M, Lee K, Kim K, Ahn M, Cho C, Kim D, et al. The maintenance ability and Ca2+ availability of skeletal muscle are enhanced by sildenafil. Exp Mol Med. 2016;48:e278 pubmed出版商
免疫沉淀; 犬; 1:1000; 图7c免疫印迹; 人类; 1:1000; 图10Hammers D, Sleeper M, Forbes S, Shima A, Walter G, Sweeney H. Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts. J Am Heart Assoc. 2016;5: pubmed出版商
Bernardini M, Brossa A, Chinigo G, Grolez G, Trimaglio G, Allart L, et al. Transient Receptor Potential Channel Expression Signatures in Tumor-Derived Endothelial Cells: Functional Roles in Prostate Cancer Angiogenesis. Cancers (Basel). 2019;11: pubmed出版商
Chen X, Taylor Nguyen N, Riley A, Herring B, White F, Obukhov A. The TRPC6 inhibitor, larixyl acetate, is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction. J Neuroinflammation. 2019;16:21 pubmed出版商
Hou X, Xiao H, Zhang Y, Zeng X, Huang M, Chen X, et al. Transient receptor potential channel 6 knockdown prevents apoptosis of renal tubular epithelial cells upon oxidative stress via autophagy activation. Cell Death Dis. 2018;9:1015 pubmed出版商
Kim E, Yazdizadeh Shotorbani P, Dryer S. Trpc6 inactivation confers protection in a model of severe nephrosis in rats. J Mol Med (Berl). 2018;96:631-644 pubmed出版商
Zhang L, Chen X, Qin H, Jiang L, Qin Y. ATRA attenuate proteinuria via downregulation of TRPC6 in glomerulosclerosis rats induced by adriamycin. Ren Fail. 2018;40:266-272 pubmed出版商
Oh M, Lee K, Huang M, Kim J, Kim D, Cho C, et al. STIM2 regulates both intracellular Ca2+ distribution and Ca2+ movement in skeletal myotubes. Sci Rep. 2017;7:17936 pubmed出版商
Ohba T, Watanabe H, Murakami M, Iino K, Adachi T, Baba Y, et al. Stromal interaction molecule 1 haploinsufficiency causes maladaptive response to pressure overload. PLoS ONE. 2017;12:e0187950 pubmed出版商
Zhang L, Ji T, Wang Q, Meng K, Zhang R, Yang H, et al. Calcium-Sensing Receptor Stimulation in Cultured Glomerular Podocytes Induces TRPC6-Dependent Calcium Entry and RhoA Activation. Cell Physiol Biochem. 2017;43:1777-1789 pubmed出版商
Hong W, Peng G, Hao B, Liao B, Zhao Z, Zhou Y, et al. Nicotine-Induced Airway Smooth Muscle Cell Proliferation Involves TRPC6-Dependent Calcium Influx Via α7 nAChR. Cell Physiol Biochem. 2017;43:986-1002 pubmed出版商
Urban N, Neuser S, Hentschel A, K??hling S, Rademann J, Schaefer M. Pharmacological inhibition of focal segmental glomerulosclerosis-related, gain of function mutants of TRPC6 channels by semi-synthetic derivatives of larixol. Br J Pharmacol. 2017;174:4099-4122 pubmed出版商
Kim E, Roshanravan H, Dryer S. Changes in podocyte TRPC channels evoked by plasma and sera from patients with recurrent FSGS and by putative glomerular permeability factors. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2342-2354 pubmed出版商
He X, Li S, Liu B, Susperreguy S, Formoso K, Yao J, et al. Major contribution of the 3/6/7 class of TRPC channels to myocardial ischemia/reperfusion and cellular hypoxia/reoxygenation injuries. Proc Natl Acad Sci U S A. 2017;114:E4582-E4591 pubmed出版商
Liu N, Zhuang Y, Zhou Z, Zhao J, Chen Q, Zheng J. NF-?B dependent up-regulation of TRPC6 by A? in BV-2 microglia cells increases COX-2 expression and contributes to hippocampus neuron damage. Neurosci Lett. 2017;651:1-8 pubmed出版商
Jadeja R, Thounaojam M, Khurana S. Characterization of pressure-mediated vascular tone in resistance arteries from bile duct-ligated rats. Oncotarget. 2017;8:30706-30722 pubmed出版商
Yang L, Liu B, Lu X, Yan Y, Zhai Y, Bao Q, et al. Inhibition of TRPC6 reduces non-small cell lung cancer cell proliferation and invasion. Oncotarget. 2017;8:5123-5134 pubmed出版商
Alvarez Miguel I, Cidad P, Pérez García M, Lopez Lopez J. Differences in TRPC3 and TRPC6 channels assembly in mesenteric vascular smooth muscle cells in essential hypertension. J Physiol. 2017;595:1497-1513 pubmed出版商
Jiang Q, Lu W, Yang K, Hadadi C, Fu X, Chen Y, et al. Sodium tanshinone IIA sulfonate inhibits hypoxia-induced enhancement of SOCE in pulmonary arterial smooth muscle cells via the PKG-PPAR-? signaling axis. Am J Physiol Cell Physiol. 2016;311:C136-49 pubmed出版商
Urban N, Wang L, Kwiek S, Rademann J, Kuebler W, Schaefer M. Identification and Validation of Larixyl Acetate as a Potent TRPC6 Inhibitor. Mol Pharmacol. 2016;89:197-213 pubmed出版商
图像 1:
Peptide (C)RRNESQDYLLMDELG corresponding to amino acid residues 24-38 of mouse TRPC6 (Accession Q61143). Intracellular N-terminus.
图像 2:
Western blot analysisof rat brain membranes: - 1.Anti-TRPC6Antibody (#ACC-017) (1:200).2. Anti-TRPC6 Antibody preincubated with the negative control antigen.
图像 3:
Expression of TRPC6 in human kidney from MN patients - Immunohistochemical staining of human biopsy specimens from MN patients FSGS patients and normal kidney tissue from tumor nephrectomy samples using Anti-TRPC6 Antibody (#ACC-017). TRPC6 expression was below detection levels in control kidneys and only slightly induced in FSGS glomeruli whereas MN kidneys mostly showed moderate to strong positivity for TRPC6.Adapted from Kistler A.D. et al. (2013) J. Biol. Chem. 288 36598. with permission of the American Society for Biochemistry and Molecular Biology.
同义词: TRPC6, Short transient receptor potential channel 6, Transient receptor protein 6, TRP6交叉活性: 人类, 小鼠, 大鼠应用: Immunocytochemistry, Immunofluorescence, Indirect Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot抗体类型: 宿主: 共轭标签/标签/标记: SwissProt号: Q61143浓度: 1毫克/毫升格式: Lyophilized powder. Reconstituted antibody contains phosphate buffered saline (PBS), pH 7.4, 1% BSA, 0.05% NaN3.缓冲液: 磷酸盐缓冲液(PBS), pH值7.4防腐剂: 1% BSA, 0.05% NaN3包装: 储存: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.纯度: Affinity purified on immobilized antigen.抗体亚型: 免疫原: 克隆性: 区域/地区/末端: Intracellular, N-terminus免疫原序列: (C)RRNESQDYLLMDELG, corresponding to amino acid residues 24-38 of mouse TRPC6类别: Ion Channels TRP Channels研究领域(s): Mechanosensing, Mechanosensitive, Breast cancer, Cancer, Renal, Kidney, Cancer, tumor, tumour, Obesity, Metabolism, Metabolic Disease, Cardiovascular, Hypertension, Pulmonary Hypertension, Vascular Hypertension更多信息或购买: Alomone Labs 蚂蚁淘页
Alomone LabsJerusalem BioPark (JBP), Hadassah Ein Kerem
P.O. Box 4287
Jerusalem 9104201info@alomone.comhttp://www.alomone.com972-2-587-2202公司总部: 以色列
Alomone Labs公司成立于1989年，在离子通道、GPCR及神经信号通路研究等领域占据全球领先地位。
