广州品牌试剂实验Athens Research代理 人体多发性骨髓瘤血浆免疫球蛋白G（IgG2）

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Haptoglobin,HumanPlasma,MixedType

触珠蛋白

ExtinctionCoefficient:1.20

Salt-freelyophilizedsolid.

Storage:-20°C

Anacute-phaseplasmaproteinfoundinhumanplasmaat100-300mgper100ml.Bindshemoglobin,thuspreventinglossofironthroughthekidneys.Humansarepolymorphicforhaptoglobin,withthreemajorphenotypes:Hp1-1,Hp2-1,andHp2-2.Whilethephenotypicdistributioncanvarygreatlybetweenethnicitiesandgeographiclocation,theHp2-1phenotypeisthemostprevalentphenotypeinhumans.PlasmaconcentrationsofhaptoglobinarehighestinindividualswithHp1-1,intermediateinHp2-1individuals,andlowestinHp2-2individuals.Hp1-1isthemosteffectiveatbindinghemoglobin,andHp2-2istheleasteffective.Thisfunctionaldifferencemaybeassociatedwiththefrequencyandseverityofepilepsyattacks,asresearchershavefoundacorrelationbetweenrecurringseizuresandtheHp2-2phenotype.

Purity:>=95%bySDS-PAGE

PreparedfromplasmashowntobenonreactiveforHBsAg,anti-HCV,anti-HBc,andnegativeforanti-HIV1&2byFDAapprovedtests.

AthensResearch&TechnologyproductsarelaboratoryreagentsandarenottobeadmiNISTeredtohumansorusedforanydrugpurpose.Forresearchuseonly.

MyeloperoxidaseEnzymeImmunoassayKit

髓过氧化物酶免疫分析试剂盒

HumanMPOEIAKITFEATURES:

USE-MeasurehumanMPOinavarietyofmatrices
SAMPLE-Serum,Platelet-PoorHeparinPlasma,Saliva,UrineorTissueCultureMedia
SAMPLES/KIT-40induplicate
SENSITIVITY-0.068ng/mL
STABILITY-liquidreagentsstableat4°C
QUICKRESULTS-2.5HOURS

Myeloperoxidase(MPO)isatetramericheme-containingproteinabundantlyproducedinneutrophilgranulocyteswhereitplaysanimportantanti-microbialrole.DuringdegranulationMPOisreleasedintotheextracellularspace.There,aspartoftheneutrophils“respiratoryburst”,itproduceshypochlorousacidfromhydrogenperoxideandCl–.MPOalsouseshydrogenperoxidetooxidizetyrosinetothetyrosylrADIcal.Bothhypochlorousacidandtyrosylarecytotoxicandwhenpresentcankillbacteriaandotherpathogens.Hereditarydeficiencyofmyeloperoxidasepredisposesindividualstoimmunedeficiency.

StudieshaveshownanassociationbetweenelevatedMPOlevelsandcoronaryarterydisease,andin2003itwassuggestedthatMPOmayserveasasensitivepredictorofmyocardialinfarctioninpatientscomplainingofchestpain.SincethattimetheclinicalutilityofMPOtestingincardiacpatientshasbeensolidlyestablishedintheliteraturewithwellover100paperspublished.In2010thisclinicalapplicationwasfurtherrefinedbyadditionalstudieswhichdeterminedthatmeasuringbothMPOandC-reactiveprotein(CRP)providedmoreaccuratepredictionofmortalityriskthanmeasuringjustCRPalone.

Myeloperoxidase,HumanNeutrophil

人嗜中性粒细胞髓过氧化物酶

100ug$85

1mg $700

MW:130,000-150,000
ExtinctionCoefficient:1.45

Lyophilizedfrom50mMNaacetate,pH6.0with100mMNaCl

Thishemeproteincatalyzesoxidationsbyhydrogenperoxide,includingMPO-chloridemediatedkillingofmicrobesandtumorcells,inactivationofhemotacticfactors,crosslinkingofproteinsandinclinationofproteins.

Activity:180-220unitspermgproteinafterlyophilization.Oneunitisdefinedastheamountofenzymethatdecomposesoneumoleofhydrogenperoxideperminuteat25oC,pH6.0.Reactionmixturecontains30mMsodiumphosphate,pH6.1,30mMguaiacol,and0.0012%(0.35mM)hydrogenperoxide.

Storage:-20°C

Purity:>=95%bySDS-PAGE

PreparedfromwholebloodshowntobenonreactiveforHBsAg,anti-HCV,anti-HBc,andnegativeforanti-HIV1&2byFDAapprovedtests.

AthensResearch&Technologyproductsarelaboratoryreagentsandarenottobeadministeredtohumansorusedforanydrugpurpose.Forresearchorfurthermanufacturinguseonly.

触珠蛋白（Haptoglobin，HP/HAP）又称结合珠蛋白，位于血浆蛋白电泳α2区带，是α2球蛋白的最主要成分。触珠蛋白是由两对α和β链通过二硫键构成的α2β2四聚体。由于有两种等位基因形成α链，所以触珠蛋白是一种具有遗传多态性的糖蛋白，有三种遗传表现型蛋白，即HP1-1，HP2-1，HP2-2。HAP表型受常染色体遗传基因控制，为常染色体不完全显性遗传，其遗传基因频率因人而异，在正常人群中分布不一

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