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MyeloperoxidaseEnzymeImmunoassayKit
髓过氧化物酶免疫分析试剂盒
HumanMPOEIAKITFEATURES:
USE-MeasurehumanMPOinavarietyofmatrices
SAMPLE-Serum,Platelet-PoorHeparinPlasma,Saliva,UrineorTissueCultureMedia
SAMPLES/KIT-40induplicate
SENSITIVITY-0.068ng/mL
STABILITY-liquidreagentsstableat4°C
QUICKRESULTS-2.5HOURS
Myeloperoxidase(MPO)isatetramericheme-containingproteinabundantlyproducedinneutrophilgranulocyteswhereitplaysanimportantanti-microbialrole.DuringdegranulationMPOisreleasedintotheextracellularspace.There,aspartoftheneutrophils“respiratoryburst”,itproduceshypochlorousacidfromhydrogenperoxideandCl–.MPOalsouseshydrogenperoxidetooxidizetyrosinetothetyrosylrADIcal.Bothhypochlorousacidandtyrosylarecytotoxicandwhenpresentcankillbacteriaandotherpathogens.Hereditarydeficiencyofmyeloperoxidasepredisposesindividualstoimmunedeficiency.
StudieshaveshownanassociationbetweenelevatedMPOlevelsandcoronaryarterydisease,andin2003itwassuggestedthatMPOmayserveasasensitivepredictorofmyocardialinfarctioninpatientscomplainingofchestpain.SincethattimetheclinicalutilityofMPOtestingincardiacpatientshasbeensolidlyestablishedintheliteraturewithwellover100paperspublished.In2010thisclinicalapplicationwasfurtherrefinedbyadditionalstudieswhichdeterminedthatmeasuringbothMPOandC-reactiveprotein(CRP)providedmoreaccuratepredictionofmortalityriskthanmeasuringjustCRPalone.
触珠蛋白(Haptoglobin,HP/HAP)又称结合珠蛋白,位于血浆蛋白电泳α2区带,是α2球蛋白的最主要成分。触珠蛋白是由两对α和β链通过二硫键构成的α2β2四聚体。由于有两种等位基因形成α链,所以触珠蛋白是一种具有遗传多态性的糖蛋白,有三种遗传表现型蛋白,即HP1-1,HP2-1,HP2-2。HAP表型受常染色体遗传基因控制,为常染色体不完全显性遗传,其遗传基因频率因人而异,在正常人群中分布不一

AthensResearchX品牌历史介绍:苏州蚂蚁淘生物科技有限公司,作为一家生命科学领域的高科技生物公司,目前代理销售二十多家欧美著名生物技术公司的产品,覆盖了免疫学、细胞生物学、分子生物学、药物筛选、生物制药、食品检测、疫苗生产等领域。