Athens Research & Technology/Alpha 1 Antitrypsin, Human Plasma/1616011609/1 mg

Synonym:α1-Proteinaseinhibitor,A1PI,AAT

MW:52,000
ExtinctionCoefficient:0.433

Lyophilizedfrom30mMNaphosphate,pH6.5,with300mMNaCl

Storage:-20°C

BuyPurifiedNativeHumanAlpha1Antitrypsin,HumanPlasma
Price$45.00/1mg.BulkQtyAvailable.

Anacute-phaseplasmaproteinfoundat95-350mgper100mlthatfunctionsasaproteaseinhibitor.Clinically,itsdeficiencyisassociatedwithtwomajordiseases:pulmonaryemphysemaandearlyonset/juvenilehepaticcirrhosis.Itiselevatedininflammatoryconditions,malignancies,liverdiseaseandpregnancyandalsoaftersurgicaltraumaanduseoforalcontraceptives.Thesimultaneousquantitativedeterminationofalpha-1-PIandceruloplasminpermitsdifferentialdiagnosisofliverafflictions.

Activity:Whentestedwithactive-sitetitratedporcinepancreatictrypsinusingNa-Benzoyl-L-Arginine-para-NitroanilideHydrochloride(L-BAPNA)assubstrate,itis75-100%inhibitory.

Purity:>=95%bySDS-PAGE

Ref:
Sinden,NicolaJ.,andRobertA.Stockley."Proteinase3activityinsputumfromsubjectswithalpha-1-antitrypsindeficiencyandCOPD." EuropeanRespiratoryJournal 41,no.5(2013):1042-1050.

PreparedfromplasmashowntobenonreactiveforHBsAg,anti-HCV,anti-HBc,andnegativeforanti-HIV1&2byFDAapprovedtests.

AthensResearch&Technologyproductsarelaboratoryreagentsandarenottobeadministeredtohumansorusedforanydrugpurpose.
Forresearchuseorforuseinfurthermanufacturing.