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Diagnostic BioSystems/Cullin-2 (CUL-2)/RP070R/Concentrated 1 ml

  • ImmunogenA peptide derived from the C-terminus region of human cullin-2.
  • SummaryThis antibody reacts with a 76kDa protein, known as cullin-2. Cullin-2 is a member of the family of human cullin genes (CUL-1, -2, -3, -4a, -4b and –5) homologous to the S. cerevisiae cdc53 gene. CUL-1 forms a complex with human p19skp1 and F box protein p45skp2, which controls the proteolysis of G1 cell cycle regulatory proteins. In contrast to CUL-1, CUL-2 does not associate with p19skp1 and p45skp2. CUL-2 forms a complex with an inactive transcriptional elongation complex, SIII, formed by three subunits: elongin C, elongin B and VHL.
  • Cellular LocalizationNuclear
  • Positive Control TissueTonsil
  • Intended UseRUO
  • Description/TypePolyclonal Rabbit Anti-Human
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