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Genemay/Mouse anti-Human CD152, Purified mAb./GMH152Z/100 �g

ProductDetails

CatalogNo./Size:GMH152Z-025/25Tests
GMH152Z-100/100Tests
Vol.per.Test:10μl/Test
Clone:A3.6B10
Isotype:MouseIgG2a
Reactivity:Human,Notyettestedinotherspecies.
Workshop:N/A
StorageBuffer:Phosphate-bufferedsolution,pH7.4,containing0.09%sodiumazideand0.2%(w/v)BSA
StorageCondition:Storeat4�C.DONOTFREEZE.LIGHTSENSITIVEMATERIAL.
Applications:FlowCytometry
ApplicationsNotes:

FACS:Use10µlfor106cells

Description:

CD152(CTLA-4).whichisexpressedonactivatedTlymphocytes2-3daysafterstimulationthroughTcellreceptor.CTLA-4hassignificantsimilaritytoCD28inaminoacidsequence,structureandgenomicorganization.FurThermoreCD152andCD28sharecommonB7familycounter-receptors.UnlikeCD28,CD152expressionappearstoberestrictedtoactivatedTcellsandCD25+CD4+regulatoryT(Treg)cells.TheregulationofCTLA-4proteinexpressioniscomplexandcaninvolvechangesintherateoftransitbetweenintracellularstoresandthecellsurface.WhereasCD28deliversacostimulatorysignalrequiredforT-cellactivation,CTLA-4isanegativeregulatorofcell-mediatedimmuneresponses.CD152mayplayrolesininductionand/ormaintenanceofimmunologicaltoleranceregulationofprotectiveimmunityandautoimmuneresponsesandregulationofsomeaspectsofthymocytematuration.



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