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Genemay/Mouse anti-Human CD5,Purified mAb./GMH005Z/25 �g

ProductDetails

CatalogNo./Size:GMH005Z-025/25ug
GMH005Z-100/100ug
Clone:UCHT2
Isotype:MouseIgG1
Reactivity:Human,Notyettestedinotherspecies.
Workshop:N/A
StorageBuffer:Phosphate-bufferedsolution,pH7.4,containing0.09%sodiumazide
StorageCondition:Storeat4�C.
Applications:FlowCytometry
ApplicationsNotes:

FACS:Thesuggesteduseofthisreagentis0.25µgper106cellsin100µlvolume.
Itisrecommendedthatthereagentbetitratedforoptimalperformanceforeachapplication.

Description:

UCHT2reactswith58kDamolecule,amemberofthescavengerreceptorsuperfamily,expressedonthymocytesandallmatureTlymphocytes.ItalsoexpressedonasmallsubsetofmatureBlymphocytes(B1acells)whichisexpandedduringfetallife,andinseveralautoimmunedisorders,aswellasinsomeB-CLL.CD5mayserveasadualreceptorwhichprovidesinhibitirysignalsinthymocytesandB1acellsandactsasacostimulatorysignalreceptor.CD5-mediatedcellularinteractionmayinfluencethymocytematurationandselection.
CD5isaphenotypicMarkerforsomeB-celllymphoproliferativedisorders(B-CLL,mantlezonelymphoma,hairycellleukemia,etc).TheincreaseofbloodCD3+/CD5-TcellscorrelateswiththepresenceofGVHD.

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