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| Catalog No./Size: | GMH152C-025/25 Tests GMH152C-100/100 Tests | |
| Vol.per.Test: | 10 μl/Test | |
| Clone: | A3.6B10 | |
| Isotype: | Mouse IgG2a | |
| Reactivity: | Human,Not yet tested in other species. | |
| Workshop: | N/A | |
| Storage Buffer: | Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide and 0.2% (w/v) BSA | |
| Storage Condition: | Store at 4�C.DO NOT FREEZE. LIGHT SENSITIVE MATERIAL. | |
| Applications: | Flow Cytometry | |
| Applications Notes: | FACS: Use 10�l for 106 cells | |
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| Description: | CD152(CTLA-4).which is expressed on activated T lymphocytes 2-3 days after stimulation through T cell receptor.CTLA-4 has significant similarity to CD28 in amino acid sequence,structure and genomic organization.Furthermore CD152 and CD28 share common B7 family counter-receptors.Unlike CD28,CD152 expression appears to be restricted to activated T cells and CD25+CD4+ regulatory T(Treg) cells. The regulation of CTLA-4 protein expression is complex and can involve changes in the rate of transit between intracellular stores and the cell surface. Where as CD28 delivers a costimulatory signal required for T-cell activation, CTLA-4 is a negative regulator of cell-mediated immune responses.CD152 may play roles in induction and/or maintenance of immunological tolerance regulation of protective immunity and autoimmune responses and regulation of some aspects of thymocyte maturation. | |