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| Catalog No./Size: | GMH0251F-025/25 Tests GMH0251F-100/100 Tests | |
| Vol.per.Test: | 10 μl/Test | |
| Clone: | GM1CD25 | |
| Isotype: | Mouse IgG2a | |
| Reactivity: | Human,Not yet tested in other species. | |
| Workshop: | N/A | |
| Storage Buffer: | Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide and 0.2% (w/v) BSA | |
| Storage Condition: | Store at 4�C.DO NOT FREEZE. LIGHT SENSITIVE MATERIAL. | |
| Applications: | Flow Cytometry | |
| Applications Notes: | FACS: Use 10µl for 106 cells | |
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| Description: | GM1CD25 reacts with CD25 antigen, a chain of low-affinity interleukin-2 receptor ( IL-2Ra ), which is expressed on activated cells including T, B, NK cells and monocytes. The antigen also prsent on subset of thymocytes, HTLV-1 transformed T cell lines, EBV transformed B cells, myeloid precursors and oligodendrocytes. The high affinity IL-2 receptor is formed by the noncovalent association of of a ( 55 kDa, CD25 ), b ( 75 kDa , CD122 ), and g subunit ( 70 kDa, CD132 ). The interaction of IL-2 with IL-2R induces the activation and proliferation of T, B , NK cells and macrophages. CD4+/CD25+ cells might directly regulate the function of responsive T cells. | |