GranuliberinRisanamphiphillicantimicrobialpeptide(AMP)originallyfoundinamphibianskin.Inmastcells,granuliberinRinduceshistaminereleaseandincreasesK+efflux.Granuliberinalsoinhibitsbasalgingivalepithelialcellproliferationinanimalmodels,potentiallythroughamechanisminvolvingsuppressionofmitoticactivity.
| CasNo. | 64704-41-2 |
|---|---|
| Purity | ≥95% |
| Formula | C69H103N19O14 |
| FormulaWt. | 1422.71 |
| IUPACName | N-[1-[(1-amino-3-hydroxy-1-oxopropan-2-yl)amino]-1-oxopropan-2-yl]-1-[2-[[2-[[2-[[2-[[1-[2-[[2-[[2-[(2-amino-3-phenylpropanoyl)amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carboxamide |
| StoreTemp | -20°C |
|---|---|
| ShipTemp | Ambient |
| InfoSheet | G6803InfoSheetPDF |
|---|
NakaoS,KomagoeK,InoueT,etal.Comparativestudyofthemembrane-permeABIlizingactivitiesofmastoparansandrelatedhistamine-releasingagentsinbacteria,erythrocytes,andmastcells.BiochimBiophysActa.2011Jan;1808(1):490-7.PMID:20955685.
KozakiewiczM,GodlewskiA.ModulationofthemitoticactivityandpopulationofthemastcellsintheoralmucosabysubstanceP.CellMolBiolLett.2003;8(3):727-34.PMID:12949612.