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Adipogen/Pifithrinα · hydrobromide/AGCR10004M005/5 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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Adipogen/Pifithrinα · hydrobromide/AGCR10004M005/5 mg
MoreInformation
ProductDetails
Synonyms1-(4-Methylphenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone.HBr,Pfithrinalpha
ProductTypeChemical
Properties
FormulaC16H18N2OS.HBr
MW286.4.80.9
CAS63208-82-2
PurityChemicals≥98%(NMR)
AppearanceWhitetooff-whitesolid.
SolubilitySolubleinDMSOor100%ethanol.
IdentityDeterminedby1H-NMR.
InChiKeyHAGVCKULCLQGRF-UHFFFAOYSA-N
ShippingandHandling
ShippingAMBIENT
ShortTermStorage+4°C
LongTermStorage-20°C
HandlingAdviceKeepunderinertgas.
Protectfromlight.
Use/StABIlityStableforatleast2yearsafterreceiptwhenstoredat-20°C.
Documents
MSDSDownloadPDF
ProductSpecificationSheet
DatasheetDownloadPDF
  • p53inhibitor[1,2]. 
  • ReversIBLyblocksp53-dependenttranscriptionalactivation[2].
  • Tooltocombatsideeffectsofcancertherapy[3].
  • Apoptosisinhibitor[1,2,4].
ProductReferences
  1. Achemicalinhibitorofp53thatprotectsmicefromthesideeffectsofcancertherapy:P.G.Komarov,etal.;Science285,1733(1999)
  2. Pifithrin-alphainhibitsp53signalingafterinteractionofthetumorsuppressorproteinwithhsp90anditsnucleartranslocation:P.J.Murphy,etal.;J.Biol.Chem.279,30195(2004)
  3. Cancerresearch.Anewwaytocombattherapysideeffects:D.Ferber;Science285,1651(1999)
  4. Inactivationofp21WAF1sensitizescellstoapoptosisviaanincreaseofbothp14ARFandp53levelsandanalterationoftheBax/Bcl-2ratio:D.Javelaud&F.Besancon;J.Biol.Chem.277,37949(2002)

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