Adipogen/Concanamycin A (high purity)/BVT0237C100/100 µg

MoreInformation
ProductDetails
Synonyms	Folimycin;AntibioticTAN1323B;AntibioticX4357B
ProductType	Chemical
Properties
Formula	C₄₆H₇₅NO₁₄
MW	866.1
CAS	80890-47-7
RTECS	CB9732000
Source/HostChemicals	IsolatedfromStreptomycessp.
PurityChemicals	≥98%(HPLC)
Appearance	Whitetooff-whitesolid.
Solubility	Solubleinmethanol,DMSOoracetonitrile;insolubleinwater.
Identity	Determinedby¹H-NMR.
Declaration	ManufacturedbyBioViotica.
InChiKey	DJZCTUVALDDONK-MSPZYORZSA-N
ShippingandHandling
Shipping	AMBIENT
ShortTermStorage	+4°C
LongTermStorage	-20°C
HandlingAdvice	Protectfromlightwheninsolution.
Use/StABIlity	Stableforatleast1yearafterreceiptwhenstoredat-20°C. Afterreconstitutionprotectfromlightat-20°C.
Documents
MSDS	DownloadPDF
ProductSpecificationSheet
Datasheet	DownloadPDF

Antibiotic.
MorepotentandspecificH⁺-ATPaseinhibitorthanbafilomycinA₁(Prod.No.BVT-0252).
InhibitsacidificationoforganellessuchaslysosomesandtheGolgiapparatus.
InhibitorofautophagicdegradationbyrisinglysosomalpHandthusinactivatingthelysosomalacidhydrolases.
Blockscellsurfaceexpressionofviralglycoproteinswithoutaffectingtheirsynthesis.
Cytotoxicinanumberofcelllinesinacellviabilityassay.
Inducesnitricoxide(NO)production.

ProductReferences

IsolationandcharacterizationofconcanamycinsA,BandC:H.Kinashi,etal.;J.Antibiot.37,1333(1984)
Folimycin(concanamycinA),aspecificinhibitorofV-ATPase,blocksintracellulartranslocationoftheglycoproteinofvesicularstomatitisvirusbeforearrivaltotheGolgiapparatus:M.Muroi,etal.;CellStruct.Funct.18,139(1993)
Folimycin(concanamycinA),aninhibitorofV-typeH(+)-ATPase,blockscell-surfaceexpressionofvirus-envelopeglycoproteins:M.Muroi,etal.;BBRC193,999(1993)
InhibitoryeffectofmodifiedbafilomycinsandconcanamycinsonP-andV-typeadenosinetriphosphatases:S.Drose,etal.;Biochemistry32,3902(1993)
InvolvementofthevacuolarH(+)-ATPasesinthesecretorypathwayofHepG2cells:M.Yilla,etal.;J.Biol.Chem.268,19092(1993)
CharacterizationoftheATPaseactivityofP-glycoproteinfrommultidrug-resistantChinesehamsterovarycells:F.J.Sharom,etal.;Biochem.J.308(Pt2),381(1995)
SpecificinhibitorsofvacuolartypeH(+)-ATPasesinduceapoptoticcelldeath:T.Nishihara,etal.;BBRC212,255(1995)
ConcanamycinA,thespecificinhibitorofV-ATPases,bindstotheV(o)subunitc:M.Huss,etal.;J.Biol.Chem.277,40544(2002)
Nitricoxideproductionbythevacuolar-type(H+)-ATPaseinhibitorsbafilomycinA1andconcanamycinAanditspossIBLeroleinapoptosisinRAW264.7cells:J.Hong,etal.;J.Pharmacol.Exp.Ther.319,672(2006)
DegradationofoxidizedproteinsbyautophagyduringoxidativestressinArabidopsis:Y.Xiong,etal.;PlantPhysiol.143,291(2007)
InhibitorsoftheV0subunitofthevacuolarH+-ATPasepreventsegregationoflysosomal-andsecretory-pathwayproteins:J.A.Sobota,etal.;J.CellSci.122,3542(2009)
InhibitorsofV-ATPase:oldandnewplayers:M.Huss,etal.;J.Exp.Biol.212,341(2009)
Increasedproductionofreactiveoxygenspeciesbythevacuolar-type(H+)-ATPaseinhibitorsbafilomycinA1andconcanamycinAinRAW264cells:A.Yokomakura,etal.;J.Toxicol.Sci.37,1045(2012)
InhibitionofvacuolarATPaseattenuatestheTRAIL-inducedactivationofcaspase-8andmodulatesthetraffickingofTRAILreceptosomes:V.Horova,etal.;FEBSJ.280,3436(2013)
Estimatingtherotationrateinthevacuolarproton-ATPaseinnativeyeastvacuolarmembranes:Z.Ferencz,etal.;Eur.Biophys.J.42,147(2013)
InhibitorsofvacuolarATPaseprotonpumpsinhibithumanprostatecancercellinvasionandprostate-specificantigenexpressionandsecretion:V.Michel,etal.;Int.J.Cancer132,E1(2013)
LossofvacuolarH+-ATPaseactivityinorganellessignalsubiquitinationandendocytosisoftheyeastplasmamembraneprotonpumpPma1p:A.M.Smardon&P.M.Kane;J.Biol.Chem.289,32316(2014)
CombinedeffectsofEGFRtyrosinekinaseinhibitorsandvATPaseinhibitorsinNSCLCcells:H.Jin,etal.;Toxicol.Appl.Pharm.278,17(2015)
AppropriatevacuolaracidificationinSaccharomycescerevisiaeisassociatedwithefficienthighsugarfermentation:T.D.Nguyen,etal.;FoodMicroBIOLOGy70,262(2018)

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Adipogen/Concanamycin A (high purity)/BVT0237C100/100 µg