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LKT/ALENDRONATE MONOSODIUM TRIHYDRATE/A4515/500 mg
ProductIDA4515
CasNo.121268-17-5
Purity≥98%
  • Description
  • ProductInfo
  • ShippingandStorage
  • Downloads
  • References

Description

Alendronateisasecondgenerationbisphosphonatethatexhibitsanti-resorptive,anti-inflammatory,immunomodulatory,andanticancerchemotherapeuticactivities.Alendronateinhibitsboneresorptionbutdoesnothaveanyeffectsonbonemineralization;italsoinhibitsosteoclastformationanddecreasesphosphorylationofAktandERK1/2invitro.Inanimalmodels,alendronatedecreasesproductionofTh4andTh17cytokinesandeotaxin-2,suppressingantigen-inducedpulmonaryimmuneresponses.Additionally,thiscompoundincreasesδγTcellactivationandinhibitstumorgrowthinvivo.

ProductInfo

CasNo.

121268-17-5

Purity

≥98%

Formula

C4H12NNaO7P2•3H2O

FormulaWt.

325.08

ChemicalName

4-Amino-1-hydroxybutylidine-1,1-bisphosphate

IUPACName

sodium;(4-amino-1-hydroxy-1-phosphonobutyl)-hydroxyphosphinate

Synonym

Alendronicacid;ABDP

MeltingPoint

233-235°C(dec)

Solubility

Solubleinwater(10mg/mL).PBS0.25mg/mL.DMSO<1>

Appearance

WhiteCrystalPowder

ShippingandStorage

StoreTemp

Ambient

ShipTemp

Ambient

Downloads

MSDS

A4515MSDSPDF

InfoSheet

A4515InfoSheetPDF

References

TsubakiM,KomaiM,ItohT,etal.Nitrogen-containingbisphosphonatesinhibitRANKL-andM-CSF-inducedosteoclastformationthroughtheinhibitionofERK1/2andAktactivation.JBiomedSci.2014Feb3;21:10.PMID:24490900.

SasakiO,ImamuraM,YamazumiY,etal.AlendronateattenuateseosinophilicairwayinflammationassociatedwithsuppressionofTh4cytokines,Th17cytokines,andeotaxin-2.JImmunol.2013Sep15;191(6):2879-89.PMID:23935198.

GutmanD,Epstein-BarashH,TsurielM,etal.Alendronateliposomesforantitumortherapy:activationofγδTcellsandinhibitionoftumorgrowth.AdvExpMedBiol.2012;733:165-79.PMID:22101722.

TakahashiH,KinbaraM,SatoN,etal.Nickelallergy-promotingeffectsofmicrobialorinflammatorysubstancesatthesensitizationstepinmice.IntImmunopharmacol.2011Oct;11(10):1534-1540.PMID:21621645.


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