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LC Labs/T-7310 Tyrphostin AG 1478, Free Base, >99%/T-7310/1 g188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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LC Labs/T-7310 Tyrphostin AG 1478, Free Base, >99%/T-7310/1 g

  • VerypotentEGFreceptorkinase(tyrosinekinase)inhibitor(IC50=3nM).VeryweakonPDGFreceptorandHER2-NEUkinases(IC50>100µM).Osherov,N.andLevitzki,A."Epidermal-growth-factor-dependentactivationofthesrc-familykinases."Eur.J.Biochem.225:1047-1053(1994).Levitzki,A.andGazit,A."Tyrosinekinaseinhibition:anapproachtodrugdevelopment."Science267:1782-1788(1995).
  • ReversIBLyinhibits(IC50=9.8µM)theratbrainKv1.5potassiumchannelinvitroinanon-protein-tyrosine-kinase-mediatedmanner.Choi,B.H.,etal."DirectinhibitionoftheclonedKv1.5channelbyAG-1478,atyrosinekinaseinhibitor."Am.J.Physiol.CellPhysiol.282:C1461-C1468(2002).
  • Soldforlaboratoryormanufacturingpurposesonly;notforhuman,medical,veterinary,food,orhouseholduse.

RelatedTerms:

[AG1478]
M.W.315.75
C16H14ClN3O2
[175178-82-2]

Storage

Storeatorbelow-20ºC

Solubility

SolubleinDMSOat50mg/mL;solubleinethanolat25mg/mLwithwarming;verypoorlysolubleinwater;maximumsolubilityinplainwaterisestimatedtobeabout10-20µM;buffers,serum,orotheradditivesmayincreaseordecreasetheaqueoussolubility

Disposal

A
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