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LC Labs/I-5890 Isoliquiritigenin, >99%/I-5890/50 mg188bio精品生物—专注于实验室精品爆款的电商平台 - 蚂蚁淘旗下精选188款生物医学科研用品
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LC Labs/I-5890 Isoliquiritigenin, >99%/I-5890/50 mg

  • IsoliquiritigeninisaLicoricechalconoid,atypeofnaturalphenol.Itactivatedsolubleguanylatecyclase,increasedcyclicGMP,andexertedavasorelaxanteffectinthephenylephrine-precontractedrataorta.YuS.M.andKuoS.C."Vasorelaxanteffectofisoliquiritigenin,anovelsolubleguanylatecyclaseactivator,inrataorta."Br.J.Pharmacol.114:1587-1594(1995).
  • BoneMorphogeneticProteins(BMPs)playanimportantroleinregulatingdevelopmentandhomeostasis.IsoliquiritigeninwasshowntobeanactivatorofBMPsignaling.VrijensK.,etal."IdentificationofsmallmoleculeactivatorsofBMPsignaling."PLoSOne8:e59045(2013).
  • Isoliquiritigenininhibitedthegrowthofcoloncarcinomainvitroandinvivo.Itprotectedthekidneyandliveragainstchemotherapy-inducedtoxicityinamousexenograftmodelofcoloncarcinoma.LeeC.K.,etal."Isoliquiritigenininhibitstumorgrowthandprotectsthekidneyandliveragainstchemotherapy-inducedtoxicityinamousexenograftmodelofcoloncarcinoma."J.Pharmacol.Sci.106:444-451(2008).
  • AnotherCASnumberpreviouslyassignedtoIsoliquiritigenin,namely78918-29-3,hasbeendeletedbyCASandisnolongerinuse.
  • Soldforlaboratoryormanufacturingpurposesonly;notforhuman,veterinary,food,orhouseholduse
M.W.256.25
C15H12O4
[961-29-5]
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