Endoglin(ENG),alsoknownasCD105,isatypeIintegraltransmembraneglycoproteinandisanaccessoryreceptorforTGF-betasuperfamilyligands.Endoglinishighlyexpressedonvascularendothelialcells,chondrocytes,andsyncytiotrophoblastsoftermplacenta.Itisalsofoundonactivatedmonocytes,mesenchymalstemcellsandleukemiccellsoflymphoidandmyeloidlineages.
Image:Image:U937cellswerestainedwithCFS-conjugatedanti-humanEndoglin/CD105(filledhistogram)orisotypecontrol(openhistogram).
TheroleofendoglinincancercanbecontrADIctingattimessinceitisneededforneoangiogenesisintumors,whichisneededfortumorgrowthandsurvival,yetthereductioninexpressionofendoglinhasinmanycancerscorrelatedwithanegativeoutcomeofthatcancer.
SouthernBiotech/Goat Anti-Human Lambda-Alexa Fluor® 555/2070-32/1.0 mg
vectorlabs/Biotinylated Aleuria Aurantia Lectin (AAL)/B-1395/1 mg
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Mouse IgG)/PK-6102/1 kit
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Universal)/PK-6200/1 kit
vectorlabs/Unconjugated Musa Paradisiaca (Banana) Lectin (BanLec)/L-1410/5 mg
GiottoBiotech/Calmodulin N60D/5 mg/G02CLM60cn