Basicfibroblastgrowthfactorisamemberofthefibroblastgrowthfactor(FGF)family.FGFfamilymemberspossessbroadmitogenicandcellsurvivalactivities,andareinvolvedinavarietyofBIOLOGicalprocesses,includingembryonicdevelopment,cellgrowth,morphogenesis,tissuerepair,tumorgrowthandinvasion.Thisproteinfunctionsasamodifierofendothelialcellmigrationandproliferation,aswellasanangiogenicfactor.Itactsasamitogenforavarietyofmesoderm-andneuroectoderm-derivedcellsinvitro,thusisthoughttobeinvolvedinorganogenesis.Threealternativelysplicedvariantsencodingdifferentisoformshavebeendescribed.Theheparin-bindinggrowthfactorsareangiogenicagentsinvivoandarepotentmitogensforavarietyofcelltypesinvitro.Therearedifferencesinthetissuedistributionandconcentrationofthese2growthfactors.
Image:FGF2proteinstructureandsequence
References:
1.Trachealcartilageregenerationbyslowreleaseofbasicfibroblastgrowthfactorfromagelatinsponge. JThoracCardiovascSurg2007Jul;134(1):170-5
2.Tissueregenerationobservedinabasicfibroblastgrowthfactor-loadedporousacellularbovinepericardiumpopulatedwithmesenchymalstemcells.JThoracCardiovascSurg2007Jul;134(1):65-73,73.e1-4
3.Theemergingroleofthefibroblastgrowthfactor-23-klothoaxisinrenalregulationofphosphatehomeostasis.JEndocrinol2007Jul;194(1):1-10
4.Prolongedprotectiveeffectofbasicfibroblastgrowthfactor-impregnatednanoparticlesinroyalcollegeofsurgeonsrats. InvestOphthalmolVisSci2007Jul;48(7):3381-7
5.Effectofbasicfibroblastgrowthfactor,trafermin,onentero-relatedfistulae,reportoftwocases. Hepatogastroenterology2007Apr-May;54(75):803-5
6.Segmentboundariesoftheadultratepididymislimitinterstitialsignalingbypotentialparacrinefactorsandsegmentslosedifferentialgeneexpressionafterefferentductligation. AsianJAndrol2007Jul;9(4):565-73
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