Insulin-likegrowthfactorI(alsoknownassomatomedinCandsomatomedinA)andinsulin-likegrowthfactorII(multiplicationstimulatingactivityorMSA)belongtothefamilyofinsulin-likegrowthfactorsthatarestructurallyhomologoustoproinsulin.MatureIGF-IandIGF-IIshareapproximately70%sequenceidentity.BothIGF-IandIGF-IIareexpressedinmanytissuesandcelltypesandmayhaveautocrine,paracrineandendocrinefunctions.MatureIGF-IandIGF-IIarehighlyconserved(100%identitybetweenhuman,bovineandporcineproteins)andexhibitcross-speciesactivity.IGF-IIisapotentmitogenicgrowthfactor.
IGF-IIbindingissignificantlyincreasedinthediabetickidneyandcouldplayaroleindiabeticneuropathy.Italsoappearstobeinvolvedsignificantlyintheprogressionofmanytumors
Image:IGF-IIstainingofParaffin-embeddedtissuesectionsofhumanplacenta(chorionicvilli).Tissuewas HRP-AECCell (red)andcounterstainedwithHaematoxylin(blue).
SouthernBiotech/Goat Anti-Human Lambda-Alexa Fluor® 555/2070-32/1.0 mg
vectorlabs/Biotinylated Aleuria Aurantia Lectin (AAL)/B-1395/1 mg
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Mouse IgG)/PK-6102/1 kit
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Universal)/PK-6200/1 kit
vectorlabs/Unconjugated Musa Paradisiaca (Banana) Lectin (BanLec)/L-1410/5 mg
GiottoBiotech/Calmodulin N60D/5 mg/G02CLM60cn