PDGFisoformsexerttheircellulareffectbybindingtothestructurallysimilarreceptortyrosinekinases(RTKs),PDGFRalphaandPDGFRbeta.PDGF-AA,PDGF-BB,PDGF-CC,PDGF-DDandPDGF-ABisofomsbindthetwodistinctcellsurfacePDGFreceptorswithdifferentaffinities.BothPDGFRalphaandPDGFRbetaaremembersoftheclassIIIsubfamilyofreceptortyrosinekinases(RTK).AllclassIIIRTKsarecharacterizedbythepresenceoffiveimmunoglobulin-likedomainsintheirextracellularregionandasplitkinasedomainintheirintracellularregion.PDGFbindinginducesreceptorhomo-andheterodimerizationleADIngtosignaltransduction.Theexpressionofalphaandbetareceptorsareindependentlyregulatedinvariouscelltypes.
Image: PDGF StaininginRαincryostattissuesectionsofmouseembryo(13d.p.c.)using15µg/mLofPDGFRAlpha.Tissueswerestainedusing HRP-DAB(red-brown)andcounterstainedwithhematoxylin(blue).
PDGFhasalsobeenlinkedtoatherosclerosis,fibrosisandmalignantdiseases.
PDGFRAlpha/CD140ACustomerPublications-(forstainingofOligodendrocyteLineage(OL)Cellssee10.1016/j.ajpath.2011.09.018.
SouthernBiotech/Goat Anti-Human Lambda-Alexa Fluor® 555/2070-32/1.0 mg
vectorlabs/Biotinylated Aleuria Aurantia Lectin (AAL)/B-1395/1 mg
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Mouse IgG)/PK-6102/1 kit
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Universal)/PK-6200/1 kit
vectorlabs/Unconjugated Musa Paradisiaca (Banana) Lectin (BanLec)/L-1410/5 mg
GiottoBiotech/Calmodulin N60D/5 mg/G02CLM60cn