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| Synonyms | Monoclonal Catenin gamma antibody, Anti-Catenin gamma antibody, Junction Plakoglobin antibody, JUP antibody |
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| Applications | ICC, IHC-F, WB |
| Immunogen | Catenin gamma antibody was raised in mouse using recombinant chicken plakoglobin as the immunogen |
| Host | Mouse |
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| Clone | CN-3 |
| Isotype | IgG1 |
| Form & Buffer | Supplied in lyophilized form |
| Storage | Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles. |
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| Usage Recommendations | Optimal conditions to be determined by the end user |
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| Biological Significance | Junction Plakoglobin (JUP),also knows as catenin gamma, is a major cytoplasmic protein that occurs in a soluble and a membrane-associated form and is the only known constituent common to the submembranous plaques of both kinds of adhering junctions, the desmosomes and the intermediate junctions. It is a component of the cadherin-catenin complex, which is predominantly localized where actin filaments anchor in adherens junctions of epithelial cells. The human plakoglobin gene localizes on chromosome 17q21. gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. |
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