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| Synonyms | MonoclonalPKBalphaantibody,Anti-PKBalphaantibody,Racproteinkinasealphaantibody,PKB-alphaantibody,ProteinkinaseBantibody,RAC-alphaantibody,ProteinkinaseBantibody,PRKBAantibody,RACantibody,RAC-alphaantibody,PKBantibody,PRKBAantibody,RACantibody,AKTantibody,AntiPKBalphaantibody,PKB-alphaantibody,RAC-PK-alphaantibody,Racproteinkinasealphaantibody,MGCmm656antibody,RAC-PK-alphaantibody,MGCmm656antibody,PKBantibody,Proto-oncogenec-aktantibody,Proto-oncogenec-aktantibody,ProteinkinaseBantibody,AKTantibody,PKBalphaantibody,ProteinkinaseBantibody |
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| Applications | WB |
| Immunogen | PKBalphaantibodywasraisedinmouseusingsyntheticpeptidecorrespondingtoaminoacids461-477ofhumanPKBalpha/Akt1astheimmunogen |
| Host | Mouse |
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| Clone | IML-26 |
| Isotype | IgG1 |
| Form&Buffer | Suppliedinlyophilizedform |
| Storage | Storeat4degCforshorttermstorage.Forlongtermstoragealiquotandstoreat-20degC,avoidrepeatedfreeze/thawcycles. |
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| UsageRecommendations | Optimalconditionstobedeterminedbytheenduser |
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| BiologicalSignificance | PKBalphaplaysacriticalroleincontrollingsurvivalandapoptosis.Thisproteinkinaseisactivatedbyinsulinandvariousgrowthandsurvivalfactorstofunctioninawortmannin-sensitivepathwayinvolvingPI3kinase.PKBalphaisactivatedbyphospholipidbindingandactivationloopphosphorylationatThr308byPDK1andbyphosphorylationwithinthecarboxyterminusatSer473.ThepreviouslyelusivePDK2responsibleforphosphorylationofAktatSer473hasbeenidentifiedasmammaliantargetofrapamycin(mTOR)inarapamycin-insensitivecomplexwithrictorandSin1. |
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