企业QQ
官方微信
| Synonyms | MonoclonalL1CAMantibody,Anti-L1CAMantibody,L1celladhesionmoleculeantibody,CAml1antibody,CD171antibody,AntigenidentifiedbymonoclonalantibodyR1antibody,MIC5antibody,MASAantibody,CD171antigenantibody,SPG1antibody,L1CAM,LCAM1,LCAM-1,LCAM1antibody,LCAM-1antibody |
|---|---|
| CrossReactivity | Human,Dog,Monkey |
| Applications | FC,IF,WB |
| Immunogen | L1CAMantibodywasraisedinmouseusingafulllengthrecombinantproteinofhumanL1CAM(NP_000416)producedinHEK293Tcells,astheimmunogen. |
| Host | Mouse |
|---|---|
| Clone | 2G9 |
| Isotype | IgG1 |
| MethodofPurification | L1CAMantibodywaspurifiedbyaffinitychromatography. |
| Form&Buffer | SuppliedinPBSbuffer,pH7.3,containing1%BSA,50%glyceroland0.02%sodiumazide. |
| Concentration | 500ug-1mg/ml |
| Storage | Storeat4degCforshorttermstorage.Aliquotandstoreat-20degCforlongtermstorage.Avoidrepeatedfreeze/thawcycles. |
|---|
| UsageRecommendations | FC:1:100,IF:1:100,WB:1:500-2000 |
|---|
| BiologicalSignificance | L1CAMisanaxonalglycoproteinbelongingtotheimmunoglobulinsupergenefamily.Theectodomain,consistingofseveralimmunoglobulin-likedomainsandfibronectin-likerepeats(typeIII),islinkedviaasingletransmembranesequencetoaconservedcytoplasmicdomain.Thiscelladhesionmoleculeplaysanimportantroleinnervoussystemdevelopment,includingneuronalmigrationanddifferentiation.MutationsinthegenecausethreeX-linkedneurologicalsyndromesknownbytheacronymCRASH(corpuscallosumhypoplasia,retardation,aphasia,spasticparaplegiaandhydrocephalus). |
|---|