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| Synonyms | MonoclonalCyclinDependentKinase6antibody,AntiCyclinDependentKinase6antibody,CDK6,CDK-6,CDK6antibody,CDK-6antibody,PLSTIREantibody,Celldivisionproteinkinase6antibody,CDK6,CDK6antibody |
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| Specificity | HumanCyclinDependentKinase6 |
| CrossReactivity | Tobedeterminedbytheenduser |
| Applications | IHC,IP,WB |
| Immunogen | CyclinDependentKinase6antibodywasraisedinmouseusinghumanrecombinantfull-lengthcdk6polypeptideastheimmunogen. |
| Host | Mouse |
|---|---|
| Clone | DCS-83 |
| Isotype | IgG1 |
| Form&Buffer | Suppliedinliquidform |
| Storage | Storeat2-8degCforshorttermstorage.Aliquotandstoreat-20degCforlongtermstorage.Avoidrepeatedfreeze/thawcycles. |
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| UsageRecommendations | Optimalconditionstobedeterminedbyenduser |
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| BiologicalSignificance | Cyclin-dependentkinases(CDKs)areafamilyofproteinkinasesfirstdiscoveredfortheirroleinregulatingthecellcycle.Theyarealsoinvolvedinregulatingtranscription,mRNAprocessing,andthedifferentiationofnervecells.Theyarepresentinallknowneukaryotes,andtheirregulatoryfunctioninthecellcyclehasbeenevolutionarilyconserved.Infact,yeastcellscanproliferatenormallywhentheirCDKgenehasbeenreplacedwiththehomologoushumangene.CDK4deficiencyhasbeenlinkedtoinsulindeficientdiabetes. |
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