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| Synonyms | MonoclonalHSPA1Aantibody,Anti-HSPA1Aantibody,Hsp70antibody,HSPA1antibody,HSPA1Bantibody,HSP70antibody,HSP70.1antibody,HSP70-1/HSP70-2antibody,Heatshock70kDaprotein1antibody,Heatshock70kDaprotein1antibody,heatshock70kDaprotein1Aantibody,HSPA1A,HSPAA1,HSPAA-1,HSPAA1antibody,HSPAA-1antibody |
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| CrossReactivity | Human,Dog,Monkey |
| Applications | FC,IF,WB |
| Immunogen | HSPA1AantibodywasraisedinmouseusingafulllengthrecombinantproteinofhumanHSPA1A(NP_005336)producedinHEK293Tcells,astheimmunogen. |
| Host | Mouse |
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| Clone | 5F3 |
| Isotype | IgG1 |
| MethodofPurification | HSPA1Aantibodywaspurifiedbyaffinitychromatography. |
| Form&Buffer | SuppliedinPBSbuffer,pH7.3,containing1%BSA,50%glyceroland0.02%sodiumazide. |
| Concentration | 500ug-1mg/ml |
| Storage | Storeat4degCforshorttermstorage.Aliquotandstoreat-20degCforlongtermstorage.Avoidrepeatedfreeze/thawcycles. |
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| UsageRecommendations | WB:1:4000,FC:1:100,IF:1:100 |
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| BiologicalSignificance | HSPA1Aisahumanheatshockprotein.Hsp70isanimportantpartofthecellsmachineryforproteinfolding,andhelpstoprotectcellsfromstress.Inmostspecies,therearemanyproteinsthatbelongtothehsp70family.Someoftheseareonlyexpressedunderstressconditions,whilesomearepresentincellsundernormalgrowthconditionsandarenotheat-inducible.Hsp70canbefoundindifferentcellularcompartments(nuclear,cytosolic,mitochondrial,endoplasmicreticulum,etc...),andthechaperonefunctionofhsp70isrequiredforprotectionagainststress-inducedapoptosis. |
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