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| Synonyms | MonoclonalKeratinK5/K8PanEpithelialantibody,AntiKeratinK5/K8PanEpithelialantibody,KeratinK/K8-5,KeratinK5/K8,KeratinK/K8-5antibody,KeratinK/K85,Cytokeratin5/8PanEpithelialantibody,KeratinK/K85antibody |
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| Specificity | HumankeratinK8 |
| CrossReactivity | Bovine,Murine,Amphibia,Pig,Fish |
| Applications | IHC,WB |
| Immunogen | KeratinK5/K8(PanEpithelial)antibodywasraisedinmouseusinghumankeratinK8,purifiedfromSDSPAGEastheimmunogen. |
| Host | Mouse |
|---|---|
| Clone | C22 |
| Isotype | IgG1 |
| Form&Buffer | Suppliedinliquidform,contains0.09%NaN3 |
| Storage | Storeat2-8degCforshorttermstorage.Aliquotandstoreat-20degCforlongtermstorage.Avoidrepeatedfreeze/thawcycles. |
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| UsageRecommendations | Optimalconditionstobedeterminedbyenduser |
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| BiologicalSignificance | KeratinK5isamemberofthekeratingenefamily.ThetypeIIcytokeratinsconsistofbasicorneutralproteinswhicharearrangedinpairsofheterotypickeratinchainscoexpressedduringdifferentiationofsimpleandstratifiedepithelialtissues.ThetypeIIcytokeratingenesareclusteredinaregionofchromosome12q12-q13.KeratinK8isspecificallyexpressedinthebasallayeroftheepidermiswithfamilymemberKRT14.AntibodiestoCK8canbeusedtodifferentiatelobularcarcinomaofthebreastfromductalcarcinomaofthebreast.Keratin8isoftenusedtogetherwithkeratin18andkeratin19todifferentiatecellsofepithelialoriginfromhematopoieticcellsinteststhatenumeratecirculatingtumorcellsinblood. |
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