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| Synonyms | MonoclonalHSPA6antibody,Anti-HSPA6antibody,HeatShock70KdaProtein6antibody,Hsp70Bantibody,HSP70antibody,HSP70-6antibody,HSPA6,HSPA6,HSPA-6,HSPA6antibody,HSPA-6antibody |
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| CrossReactivity | Human |
| Applications | IF,WB |
| Immunogen | HSPA6antibodywasraisedinmouseusingafulllengthrecombinantproteinofhumanHSPA6(NP_002146)producedinHEK293Tcells,astheimmunogen. |
| Host | Mouse |
|---|---|
| Clone | 1E11 |
| Isotype | IgG2a |
| MethodofPurification | HSPA6antibodywaspurifiedbyaffinitychromatography. |
| Form&Buffer | SuppliedinPBSbuffer,pH7.3,containing1%BSA,50%glyceroland0.02%sodiumazide. |
| Concentration | 500ug-1mg/ml |
| Storage | Storeat4degCforshorttermstorage.Aliquotandstoreat-20degCforlongtermstorage.Avoidrepeatedfreeze/thawcycles. |
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| UsageRecommendations | IF:1:100,WB:1:500-2000 |
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| BiologicalSignificance | Incooperationwithotherchaperones,Hsp70sstabilizepreexistentproteinsagainstaggregationandmediatethefoldingofnewlytranslatedpolypeptidesinthecytosolaswellaswithinorganelles.Thesechaperonesparticipateinalltheseprocessesthroughtheirabilitytorecognisenonnativeconformationsofotherproteins.Theybindextendedpeptidesegmentswithanethydrophobiccharacterexposedbypolypeptidesduringtranslationandmembranetranslocation,orfollowingstress-induceddamage. |
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