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| Synonyms | MonoclonalCaspase7antibody,anti-Caspase7antibody,ICE-LAP3antibody,EC3.4.22.60antibody,MCH3antibody,CASP7antibody,Caspase-7,Caspase-7antibody,Caspase7antibody,Caspase7,CMH-1antibody,Caspase7,CASP-7antibody |
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| CrossReactivity | Human,Mouse,Rat |
| Applications | IP,WB |
| Immunogen | Caspase7antibodywasraisedinMouseusingsyntheticpeptidefromhumancaspase-7astheimmunogen. |
| Host | Mouse |
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| Clone | B4-G2 |
| Isotype | IgG1 |
| MethodofPurification | Caspase7antibodywaspurifiedbyaffinitychromatography |
| Form&Buffer | SuppliedinPBSbuffercontaining1mg/mlBSAand1.5mMthimerosaland50%glycerol |
| Concentration | 500ug/ml |
| Storage | Storeat4degCforshorttermstorage.Aliquotandstoreat-20degCforlongtermstorage.Avoidrepeatedfreeze/thawcycles. |
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| UsageRecommendations | IP:4-10ug/ml,WB:0.5-2ug/ml |
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| BiologicalSignificance | Thecaspasefamilyofcysteineproteasesplaysakeyroleinapoptosis.Caspase-7,alsoknownasMch3alpha,ICE/LAP3andCMH1,isa34kDaproteinthatisactivatedduringFas-andTNF-inducedapoptosis.Caspase-7hasbeenidentifiedasamajorcontributortotheexecutionphaseofcellularapoptosis.Itcleavesessentialcellularmachineryfollowingitsowncleavagefromaninactiveproenzymetoanactiveheterodimericform.Caspase-7isprocessedbycaspase-3,-6,-8,-9,and–10aswellasbyGranzymeB. |
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