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| Synonyms | MonoclonalCOTL1antibody,AntiCOTL1antibody,Coactosin-likeproteinantibody,CLPantibody,FLJ43657antibody,MGC19733antibody |
|---|---|
| Specificity | Human |
| Applications | ELISA,WB |
| Immunogen | COTL1antibodywasraisedinmouseusingrecombinanthumanCOTL1(1-142aa)purifiedfromE.coliastheimmunogen |
| Host | Mouse |
|---|---|
| Clone | AT1D6 |
| Isotype | IgG2b,k |
| Source | COTL1antibodyisderivedfromhybridizationofmouseF0myelomacellswithspleencellsfromBALB/cmiceimmunizedwitharecombinanthumanCOTL1protein. |
| MethodofPurification | COTL1antibodyispurifiedbyProteinAaffinitychromatography |
| Form&Buffer | SuppliedasliquidinPBS(pH7.4)containing10%glycerol,0.02%NaN3. |
| Concentration | 1mg/ml |
| Storage | Storeat4degCshortterm.Forlongtermstorage,aliquotandstoreat-20degCandavoidrepeatedfreeze/thawcycles. |
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| UsageRecommendations | Recommendedstartingdilutionis1:1000 |
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| BiologicalSignificance | COTL1(coactosin-like1),alsoknownasCLP,isa142aminoacidcytoplasmicandcytoskeletalproteinthatbelongstotheactin-bindingproteinsADFfamilyandcoactosinsubfamily.COTL1isfirstidentifiedinslimemoldandisfoundathighestlevelsinkidney,placenta,lungandperipheralbloodleukocytes.COTL1isoneofmanyproteinsthatparticipateinregulationofActin?scytoskeletonthroughacalciumdependentmechanism,buthasnotbeenshowntohaveadirecteffectonActindepolymerization. |
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