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| Synonyms | MonoclonalPGA5antibody,Anti-PGA5antibody,Pepsinogen5groupIantibody,PepsinogenAantibody,PGA5,PGA5,PGA-5,PGA5antibody,PGA-5antibody |
|---|---|
| CrossReactivity | Human |
| Applications | ELISA,IHC,WB |
| Immunogen | PGA5antibodywasraisedinMouseusingapurifiedrecombinantfragmentofhumanPGA5expressedinE.coliastheimmunogen. |
| Host | Mouse |
|---|---|
| Clone | 2C1 |
| Isotype | IgG1 |
| Form&Buffer | Suppliedasaliquidinasciticfluidcontaining0.03%sodiumazide. |
| Concentration | 1.0mg/ml |
| Storage | Storeat4degCforshorttermstorage.Storeat-20degCforlongtermstorage.Avoidrepeatedfreeze/thawcycles. |
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| UsageRecommendations | ELISA:1:10,000,IHC:1:200-1:1000,WB:1:500-1:2000 |
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| BiologicalSignificance | Pepsinogensaretheinactiveprecursorsofpepsin,themajoracidproteasefoundinthestomach.Pepsinisoneofthemainproteolyticenzymessecretedbythegastricmucosa.Pepsinconsistsofasinglepolypeptidechainandarisesfromitsprecursor,pepsinogen,byremovalofa41aminoacidsegmentfromtheN-terminus.Pepsinisparticularlyeffectiveincleavingpeptidebondsinvolvingaromaticaminoacids.Pepsinshowsextremelybroadspecificity;althoughbondsinvolvingphenylalanineandleucinearepreferred,manyothersarealsocleavedtosomeextent.PGA5isamemberofthesubfamilyA1withinthepepsinfamilyandisthepredominantendopeptidaseinthegastricjuiceofvertebrates. |
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