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| Synonyms | MonoclonalDDX48antibody,Anti-DDX48antibody,MGC10862antibody,DDX48,DDX48antibody,KIAA0111antibody,NUK-34antibody,Eukaryotictranslationinitiationfactor4Aisoform3antibody,DDX48,DDX-48,eIF4AIIIantibody,DDX-48antibody,hNMP265antibody,EIF4A3antibody |
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| Specificity | HumanDDX48 |
| CrossReactivity | Human.Otherspeciesnotstudied |
| Applications | DotBlot |
| Immunogen | DDX48antibodywasraisedinmouseusingrecombinantHumanDead(Asp-Glu-Ala-Asp)BoxPolypeptide48(Ddx48) |
| Host | Mouse |
|---|---|
| Clone | 2256C1 |
| Isotype | IgG1 |
| MethodofPurification | DDX48antibodywaspurifiedusingproteinGcolumnchromatographyfromculturesupernatantofhybridomaculturedinamediumcontainingbovineIgG-depleted(approximately95%)fetalbovineserum. |
| Form&Buffer | DDX48antibodyinPBS(3.0mMKCl,1.5mMKH2PO4,140mMNaCl,8.0mMNa2HPO4(pH7.4))containing1%bovineserumalbumin(BSA)and0.05%sodiumazide(NaN3). |
| Concentration | 100ug/ml |
| Storage | Storeat2-8degCforuptooneyear.Werecommendlongtermstorageat-20degC.Avoidrepeatedfreezingandthawing. |
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| BiohazardInformation | Thisantibodysolutioncontainssodiumazide(NaN)asapreservative.ThereisapotentialhazardthatNaNreactswithcopperorleadtoproduceanexplosivecompound.Forsafedisposal,thevialhastobewashedthoroughlywithwater.Itisstronglyadv |
| UsageRecommendations | Tobeoptimizedbytheenduser. |
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| BiologicalSignificance | ThisgeneencodesamemberoftheDEADboxproteinfamily.DEADboxproteins,characterizedbytheconservedmotifAsp-Glu-Ala-Asp(DEAD),areputativeRNAhelicases.TheyareimplicatedinanumberofcellularprocessesinvolvingalterationofRNAsecondarystructure,suchastranslationinitiation,nuclearandmitochondrialsplicing,andribosomeandspliceosomeassembly.Basedontheirdistributionpatterns,somemembersofthisfamilyarebelievedtobeinvolvedinembryogenesis,spermatogenesis,andcellulargrowthanddivision.Theproteinencodedbythisgeneisanuclearmatrixprotein.ItsaminoacidsequenceishighlysimilartotheaminoacidsequencesofthetranslationinitiationfactorseIF4AIandeIF4AII,twoothermembersoftheDEADboxproteinfamily. |
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