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| Synonyms | MonoclonalSNCAantibody,Anti-SNCAantibody,alphaSynucleinantibody,NACPantibody,PARK1antibody,NonA4componentofamyloidprecursorantibody,Non-A-betacomponentofalzheimersdiseaseamyloidantibody,precursorofantibody,PARK1antibody,PARK4antibody,PARK4antibody,Parkinsondiseasefamilial1antibody,PD1antibody,PD1antibody,Sncasynucleinantibody,alpha(nonA4componentofamyloidprecursor)antibody,Synucleinalphaantibody,Synucleinantibody,alpha(nonA4componentofamyloidprecursor)antibody,alpha-SynucleinDelta-NACantibody,Non-AbetacomponentofADamyloidantibody,Non-A4componentofamyloidprecursorantibody,NACPantibody,alpha-synucleinantibody,alphasynucleinantibody,alpha-synucleinantibody,isoformNACP140antibody,alphaSYNantibody,MGC105443antibody,MGC110988antibody,MGC127560antibody,MGC64356antibody,NonAbetacomponentofADamyloidantibody |
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| Applications | IF,WB |
| Host | Mouse |
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| Clone | 3H9 |
| Isotype | IgG1 |
| Form&Buffer | SuppliedinliquidforminAscitesfluidwith0.01%NaN3 |
| UsageRecommendations | WB:1:1000,IF:1:500 |
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| BiologicalSignificance | Alpha-synuclein(aminoacids1-140),anacidicneuronalproteinof140aminoacids,isextremelyheat-resistantandisnativelyunfoldedwithanextendedstructureprimarilycomposedofrandomcoils.alpha-synucleinhasbeensuggestedtobeimplicatedinthepathogenesisofParkinsonsdiseaseandrelatedneurodegenerativedisorders,andmorerecently,tobeanimportantregulatorycomponentofvesiculartransportinneuronalcells.Specially,thenon-Abetacomponentofamyloidplaques(NAC,aminoacids61-95)isahighlyamyloidogenicpeptideconsistingof35aminoacidswhichwasfirstidentifiedassociatedwithsenileplaquesintheAlzheimersdiseasebrain. |
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