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| Synonyms | MonoclonalIntegrinalpha3Bantibody,Anti-Integrinalpha3Bantibody,ITG3bantibody,ITGA3antibody,Integrinalpha3B |
|---|---|
| Specificity | Recognizesspecificallythecytoplasmicdomainofintegrinsubunitalpha3Bwhichispresentinmicrovascularstructuresinbrainandheart |
| CrossReactivity | Human |
| Applications | IHC,IHC-F,WB |
| Immunogen | Integrinalpha3BantibodywasraisedinMouseusingasyntheticpeptidecorrespondingtoa32aminoacidstretchinthecytoplasmicdomainofintegrinalpha3BincludinganappendingN-terminalcysteine(CTRYYQIMPKYHAVRIREEERYPPPGSTLPTKK)coupledtokey |
| Host | Mouse |
|---|---|
| Clone | 54B3 |
| Isotype | IgG1 |
| Form&Buffer | SuppliedinPBScontaining0.09%sodiumazide |
| UsageRecommendations | IHC:1:25-1:200,WB:1:100-1:1000 |
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| BiologicalSignificance | Cadherinsconstituteafamilyofproteins,themembersofwhicharedifferentiallyexpressedinthedifferenttissues.OneofthebestcharacterizedmembersisE-cadherin,whichisprevalentinepithelialtissues.Ithasbeenshowntoplayacrucialroleintheprocessoftumorcellmetastasis.NCAM’s(neuralcelladhesionmolecules)existinatleastthreeformsofplasmamembraneplycoproteins,whichareexpressedinavarietyoftissuesincludingmostnervecells. |
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