企业QQ
官方微信
| Synonyms | MonoclonalSOCS3antibody,Anti-SOCS3antibody,Suppressorofcytokinesignaling3antibody,CIS3antibody,SSI3antibody,Cish3antibody,Cytokine-inducibleSH2protein3antibody,STAT-inducedSTATinhibitor3antibody,SOCS3,SOCS3,SOCS-3,SOCS3antibody,SOCS-3antibody |
|---|---|
| CrossReactivity | Human |
| Applications | FC,IF,IHC,WB |
| Immunogen | SOCS3antibodywasraisedinmouseusingafulllengthrecombinantproteinofhumanSOCS3(NP_003946)producedinHEK293cellastheimmunogen. |
| Host | Mouse |
|---|---|
| Clone | 7E10 |
| Isotype | IgG1 |
| MethodofPurification | SOCS3antibodywaspurifiedbyaffinitychromatography. |
| Form&Buffer | SuppliedinPBSbuffer,pH7.3,containing1%BSA,50%glyceroland0.02%sodiumazide. |
| Concentration | 500ug-1mg/ml |
| Storage | Storeat4degCforshorttermstorage.Aliquotandstoreat-20degCforlongtermstorage.Avoidrepeatedfreeze/thawcycles. |
|---|
| UsageRecommendations | FC:1:100,IF:1:100,IHC:1:150,WB:1:2000 |
|---|
| BiologicalSignificance | SOCS3isamemberoftheSTAT-inducedSTATinhibitor(SSI),alsoknownassuppressorofcytokinesignaling(SOCS),family.SSIfamilymembersarecytokine-induciblenegativeregulatorsofcytokinesignaling.Theexpressionofthisgeneisinducedbyvariouscytokines,includingIL6,IL10,andinterferon(IFN)-gamma.TheproteinencodedbythisgenecanbindtoJAK2kinase,andinhibittheactivityofJAK2kinase.Studiesofthemousecounterpartofthisgenesuggestedtherolesofthisgeneinthenegativeregulationoffetalliverhematopoiesis,andplacentaldevelopment. |
|---|