企业QQ
官方微信
RabbitAnti-phospho-ATF4(Ser245) antibody
| 产品编号 | hz-5190R |
| 英文名称 | phospho-ATF4(Ser245) |
| 中文名称 | ***酸化活化转录因子4抗体 |
| 别 名 | ATF4(phosphoS245);ATF4(Phospho-Ser245);CyclicAMPresponseelementbindingprotein2;DNAbindingproteinTAXREB67;ActivatingTranscriptionFactor4;ATF4;ATF4protein;CREB2;CREB2;CREB-2;CyclicAMPdependenttranscriptionfactorATF4;TaxResponsiveEnhancerElementB67;TAXREB67;TXREB;ATF4_HUMAN. |
| 产品类型 | ***酸化抗体 |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 细胞凋亡 转录调节因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） notyettestedinotherapplications.optimaldilutions/concentrationsshouldbedeterminedbytheenduser. |
| 分 子 量 | 38kDa |
| 细胞定位 | 细胞核 细胞浆 细胞膜 |
| 性 状 | LyophilizedorLiquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLHconjugatedSynthesisedphosphopeptidederivedfromhumanATF4aroundthephosphorylationsiteofSer245:NR(p-S)LP |
| 亚 型 | IgG |
| 纯化方法 | affinitypurifiedbyProteinA |
| 储 存 液 | 0.01MTBS(pH7.4)with1%BSA,0.03%Proclin300and50%Glycerol. |
| 保存条件 | Storeat-20°Cforoneyear.Avoidrepeatedfreeze/thawcycles.Thelyophilizedantibodyisstableatroomtemperatureforatleastonemonthandforgreaterthanayearwhenkeptat-20°C.WhenreconstitutedinsterilepH7.40.01MPBSordiluentofantibodytheantibodyisstableforatleasttwoweeksat2-4°C. |
| PubMed | PubMed |
| 产品介绍 | background:ATF4isatranscriptionfactorthatwasoriginallyidentifiedasawidelyexpressedmammalianDNAbindingproteinthatcouldbindatax-responsiveenhancerelementintheLTRofHTLV1.TheencodedproteinwasalsoisolatedandcharacterizedasthecAMP-responseelementbindingprotein2(CREB2).TheproteinencodedbythisgenebelongstoafamilyofDNA-bindingproteinsthatincludestheAP1familyoftranscriptionfactors,cAMP-responseelementbindingproteins(CREBs)andCREB-likeproteins.Thesetranscriptionfactorssharealeucinezipperregionthatisinvolvedinprotein-proteininteractions,locatedC-terminaltoastretchofbasicaminoacidsthatfunctionsasaDNAbindingdomain(referencedfromEntrezgene).Function:Transcriptionalactivator.BindsthecAMPresponseelement(CRE)(consensus:5-GTGACGT[AC][AG]-3),asequencepresentinmanyviralandcellularpromoters.ItbindstoaTax-responsiveenhancerelementinthelongterminalrepeatofHTLV-I.SubcellularLocation:Cytoplasm.Cellmembrane.Nucleus.ColocalizeswithGABBR1inhippocampalneurondendriticmembranes.Similarity:BelongstothebZIPfamily.Contains1bZIPdomain.SWISS:P18848GeneID:468Databaselinks: EntrezGene:468Human EntrezGene:11911Mouse EntrezGene:79255Rat NCBI:33469976Human Omim:604064Human SwissProt:P18848Human SwissProt:Q96AQ3Human SwissProt:Q06507Mouse SwissProt:Q5U4B2Mouse SwissProt:Q8CF69Mouse SwissProt:Q9ES19Rat Unigene:496487Human Unigene:641Mouse Unigene:2423Rat ImportantNote:Thisproductassuppliedisintendedforresearchuseonly,notforuseinhuman,therapeuticordiagnosticapplications. |