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Bertin Pharma/Naringenin/14173/1 g

ProductOverview:
Acitrus-derivedflavonoidthatinhibitsCYP3A4activityinhumanlivermicrosomes(IC50s=139-188μM);demonstratesantifibrotic,lipidlowering,andinsulin-likeproperties
Naringeninisacitrus-derivedflavonoidthatinhibitsCYP3A4activityinhumanlivermicrosomes(IC50s=139-188μM).At100mg/kg/day,naringeninselectivelyinhibitsthetranscriptionofSmad3anddirectlydown-regulatesTGF-β1,significantlyreducinglungmetastasisinmicewithbleomycin-inducedpulmonaryfibrosis.Naringenindemonstratesbothlipidloweringandinsulin-likepropertiesinlow-densitylipoprotein(LDL)receptor-deficientmicefedaWesterndietcontaining1-3%naringeninbycorrectingVLDLoverproduction,amelioratinghepaticsteatosis,andattenuatingdyslipidemiawithoutaffectingcaloricintakeorfatabsorption.

Data:

Size:1g
Shipping:wetice
StABIlity:Storeat-20degrees;shelflife730daysmaximumafterproduction
CASNumber:67604-48-2
MolecularFormula:C15H12O5
SMILES:OC(C=C1)=CC=C1C2CC(C3=C(O)C=C(O)C=C3O2)=O
MolecularWeight:272.3
Formulation:Acrystallinesolid
Purity:≥98%
CustomCode:2907299000
UNSPSCcode:12352100
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