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Bertin Pharma/FLLL32/10638/1 mg

Product Overview:
,An inhibitor of JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50 ~ 5 µM); blocks signaling from IFN-α or IL-6 through JAK2/STAT3 and induces apoptosis in several types of cancer cells
FLLL32 is a cell-permeable analog of curcumin (Item No. 81025) that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50 = ~ 5 µM). It blocks signaling from IFN-α or IL-6 through JAK2/STAT3 and induces apoptosis in several types of cancer cells. FLLL32 does not interfere with IFN-γ-induced STAT1 signaling and does not adversely affect the function or viability of immune cells. Through its effects on JAK2/STAT3 signaling, FLLL32 enhances the chemo- and radiosensitivity of cancer cells.

Data:

Size: 1 mg
Shipping: dry ice
Stability: Store at -20 degrees; shelf life 730 days maximum after production
CAS Number: 1226895-15-3
Molecular Formula: C28H32O6
SMILES: O=C(/C=C/C1=CC(OC)=C(OC)C=C1)C2CCCC(C(/C=C/C3=CC(OC)=C(OC)C=C3)=O)C2
Molecular Weight: 464.6
Formulation: A crystalline solid
Purity: ≥98%
Custom Code: 2909300000
UNSPSC code: 12352100
UN Number: UN3077
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