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The mission of Lucerna is to be the market leader in the development of RNA-based research reagents that enable scientific discovery.
Lucerna was launched in 2010 by scientists who developed the Spinach™ technology. Spinach, a RNA mimic of the green fluorescent protein (GFP), was developed in the laboratory of Dr. Samie Jaffrey of Weill Cornell University. Since then, over 50 articles have been published on the Spinach™ technology.
Lucerna licensed the Spinach™ technology from Cornell University with the goal of developing "scientists friendly" tools to help propel this burgeoning RNA era.
Lucerna's first RNA imaging product, DFHBI fluorophore, was launched in 2011.
DFHBI is a small molecule dye that fluoresces when bound to the Spinach aptamer. RNA that genetically encodes the Spinach tag can be expressed in cells and with the addition of DFHBI, living RNA localization and movements can now be visible under the microscope.
The development and testing of the Spinach aptamer and DFHBI fluorophore was first described in Paige, et al., Science, 2011.
DFHBI-1T, a brighter and more photostable fluorophore, was launched in 2014. Soon after, new aptamer tags that have different properties or fluoresce in different colors (Broccoli, Corn, Red Broccoli, and Radish) were also introduced.
The Spinach aptamer was originally named as homage to the late Dr. Roger Tsien. Dr. Tsien named all of fluorescent proteins developed in his labs after fruits (e.g. mCherry, dTomato, mApple, mCitrine, etc.). Following this tradition, all aptamers derived from the Spinach™ technology are named after vegetables that best match their fluorescent colors.
Lucerna received a $1.5M phase II SBIR grant from the National Cancer Institute to develop a high-throughput drug screening platform to identify drugs that can correct a splicing event key to cancer's metabolic pathway. This platform uses the Spinach™ technology to generate fluorescent sensors that can detect endogenous splice isoforms in cells.
In 2017, Lucerna also successfully completed a R&D project for a top 5 pharma company to develop a custom splicing assay to identify novel splice modulating hits.
Our splicing drug discovery platform is high-throughput compatible, can target any endogenous spliced isoforms, and can detect hits that cause as small as 10% splicing changes.
Lucerna is always looking for ways to develop unique research and drug discovery tools to help solve urgent problems in the RNA world.
Current technologies in development include:
• Cell-based antiviral drug discovery platforms
• Enhanced fluorophores that allow single-molecule RNA imaging in live cells.
• Fluorescent sensors that report changes in RNA structures.
• Sensors that detect intracellular metabolic changes for drug discovery and for industrial biotechnology applications.
Proprietary dyes that turns on the fluorescence of the Spinach family of RNA aptamers.
High-throughput compatible assays with homogenous workflows and robust fluorescence readouts.
Custom fluorescent sensors that detect medically important RNAs with specificity and sensitivity.
苏州蚂蚁淘生物科技有限公司专注于为科研工作者提供CST，Abcam，Sigma，biorbyt，Abclonal，AbD Serotec，GeneTex，ENZO，ScienCell，BI，Swant，emfret，Biovision，Roche，Millipore，BD，Life，eBioscience，Thermo，Qiagen，Santa，Peprotech，R&D，ImmunoStar，GenStar，GeneCopoeia，Cusabio，Bioss，NeoBioscience
品牌 Absolute/美国 供货周期 现货 北京百奥创新代理Orflo Technologies在中国的业务。Orflo Technologies代理，Orflo Technologies代理，Orflo Technologies华东代理，Orflo Technologies 华北代理，Orflo Technologies华中代理，Orflo Technologies华南代理，Orflo Technologies全国代理 详细介绍 北京百奥创新代理Orflo Technologies在中国的业务。Orflo Technologies代理，Orflo Technologies代理，Orflo Technologies华东代理，Orflo Technologies华北代理，Orflo Technologies华中代理，Orflo Technologies华南代理，Orflo Technologies全国代理 Orflo Technologies是一家生命科学公司，致力于为细胞和蛋白质分析行业开发和销售强大而简单的仪器。 Orflo仪器的核心是保护的μFlow细胞盒。通过阻抗（Coulter Principle）和基于荧光的流动的独特组合，流式细胞仪Orflo的仪器通过同时直接测量荧光和细胞体积，为细胞分析提供了一个信息丰富且直观的窗口。再加上业界的易用性，经济性，消除所有流体和维护将大大提高试验，测试和zui终发现的速度。Orflo Technologies全国代理 Cell Health ORFLO has developed Cell Health Assays, designed for optimal performance on their flow cytometry instruments. Moxi Cyte Viability (PI) Cell health monitoring and QC has never been easier and more affordable. ORFLO has launched a range of complimentary state of the art flow cytometry instruments and reagents geared toward greatly simplifying the process of cell health monitoring now. ORFLO has a range of cell culture and enumeration assays designed for optimal performance on their cell count and flow cytometry instruments.聽 Accumax Orflo Accumax is a cell dissassociation reagent tailored for impedance based flow cytometry and specially formulated to provide optimal flow travel in Orflo Flow sensor cassettes. Particularly useful for generating single cell suspensions. Accumax is specifically designed for our combination fluorescence & impedance based flow cytometers. This is a solution of proteolytic, collagenolytic and DNase enzymes and does not contain mammalian or bacterial derived products. Accutase Orflo Accutase is a cell dissaccociation agent for mammalian cells for use with Moxi Z and Moxi flow devices. Accutase庐 is a cell detachment solution containing proteolytic and collagenolytic enzymes, which are neither mammalian nor bacterial derived. It is a replacement for Trypsin-EDTA solution and is useful for the detachment of cells from standard tissue culture plasticware and adhesion coated plasticware, and polymers. Accutase庐 works exceptionally well for detaching cell lines for continued cell culturing, analysis of cell surface markers, virus growth assays, quiescence assays by serum starvation, transformation assays by oncogene transfection, neural crest cell migration assays, cell proliferation, cell haptotaxis, and tumor cell migration assays. Moxi Z System Check Beads Utilize the Moxi Z System Check Beads to periodically check count accuracy. You must flow the Moxi Z System Check Bead protocol to ensure accurate results Moxi Flow System Check Beads Utilize the Moxi Z System Check Beads to periodically check count accuracy. You must flow the Moxi Z System Check Bead protocol to ensure accurate results 1 mL (with surfactant) 5 mL (with surfactant) Moxi Z Diluent MXC002 Moxi Z Cell Count Cassettes Type S orflo 25 pack Orflo Diluent is special formulated for Orflo flow sensor cassettes and is recommended for use with the Moxi Z and Moxi Flow platforms when cell concentrations are above 2 million cells per ml. It is also recommended if media conductivity is not in the range of 300-360 mOsm.