OTHERTOOLSANDRESOURCES
REFERENCEFORTHEPRODUCT:
Globalanalysisoflysineubiquitinationbyubiquitinremnantimmunoaffinityprofiling. XuG,PaigeJS,JaffreySR.NatureBiotechnology. 2010Aug;28(8)868-73.
THISPRODUCTWASCITEDIN:
A proteome-wide, quantitative survey ofinvivo ubiquitylation sites reveals widespread regulatory roles. WagnerSA, etal. Molecular&CellularProteomics. 2011Sep.
Proteomicanalysesrevealdivergentubiquitylationsitepatternsinmurinetissues.WagnerSA,etal. Molecular&CellularProteomics.2012Jul.
Systems-wideanalysisofubiquitylationdynamicsrevealsakeyroleforPAF15ubiquitylationinDNA-damagebypass.PovlsenLK,etal. NatureCellBIOLOGy. 2012Sep.
SpeciesReactivity | KeyApplications | Host | Format | AntibodyType |
Human,mouse,rat,chicken,yeast,cowhorse | WB,IP | Mouse | Purified | MonoclonalAntibody |
QUALITYASSURANCE:EachantibodybatchwillbemeasuredforitsABIlitytobindtoproteinscontainingdiglycyl-lysineandtorecoverdiglycyl-lysine-containingpeptidesfromtrypticdigestsofHEK293cells.
USAGESTATEMENT:Thisproductisintendedforresearchuseonlyandarenottobeusedforanyotherpurpose,whichincludesbutisnotlimitedto,unauthorizedcommercialuses,invitrodiagnosticuses,exvivoorinvivotherapeuticusesoranytypeofconsumptionorapplicationtohumansoranimals.Duetothehighlyspecificnatureofantibodiesandantigens,wecannotpredictorbeheldresponsIBLewithrespecttohowLucernaTMproductswillbehaveinitscustomers"systems.ResearchersusingLucernaTMproductsshouldconductoptimizationstudiestoachievetheoptimalresultpossiblefortheirintendedapplication.
LICENSING:CornellUniversityhasfiledausepatentonproteomicmethodsthatusethediglycyl-lysineantibodytoidentifyubiquitinatedproteins.Allcommercial usersshouldcontactCornellUniversityforauselicense.
GX41antibodyrecognizesthediglycyl-lysinemoietyatubiquitinatedsites.
Specificityofanti-diglycyl-lysine(cloneGX41)isverifiedbywesternblotanalysisofbeta-lactoglobulin,lysozyme,orratbrainlysate,inwhichthelysineswereeitherunmodified(A)ormodifiedwithBoc-Gly-Gly(B),respectively.
Equimolaramountsofthetwopeptides(GGDRVYIHPFHLandAc-SYSMEHFRWGK*PV-NH2)wereimmunoprecipitatedwithimmobolizedGX41antibodyandanalyzedbyMALDI-TOFMS.
SouthernBiotech/Goat Anti-Human Lambda-Alexa Fluor® 555/2070-32/1.0 mg
vectorlabs/Biotinylated Aleuria Aurantia Lectin (AAL)/B-1395/1 mg
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Mouse IgG)/PK-6102/1 kit
vectorlabs/VECTASTAIN® Elite® ABC-HRP Kit (Peroxidase, Universal)/PK-6200/1 kit
vectorlabs/Unconjugated Musa Paradisiaca (Banana) Lectin (BanLec)/L-1410/5 mg
GiottoBiotech/Calmodulin N60D/5 mg/G02CLM60cn