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蚂蚁淘生物做为Lucerna的一级代理商，竭诚为您服务！
【订购】蚂蚁淘生物科技 联系方式：4000-520-616
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苏州蚂蚁淘生物科技有限公司
咨询热线：4000-520-616
蚂蚁淘官网：https://www.ebiomall.cn/
The mission of Lucerna is to be the market leader in the development of RNA-based research reagents that enable scientific discovery.
Lucerna was launched in 2010 by scientists who developed the Spinach™ technology. Spinach, a RNA mimic of the green fluorescent protein (GFP), was developed in the laboratory of Dr. Samie Jaffrey of Weill Cornell University. Since then, over 50 articles have been published on the Spinach™ technology.
Lucerna licensed the Spinach™ technology from Cornell University with the goal of developing "scientists friendly" tools to help propel this burgeoning RNA era.
Lucerna's first RNA imaging product, DFHBI fluorophore, was launched in 2011.
DFHBI is a small molecule dye that fluoresces when bound to the Spinach aptamer. RNA that genetically encodes the Spinach tag can be expressed in cells and with the addition of DFHBI, living RNA localization and movements can now be visible under the microscope.
The development and testing of the Spinach aptamer and DFHBI fluorophore was first described in Paige, et al., Science, 2011.
DFHBI-1T, a brighter and more photostable fluorophore, was launched in 2014. Soon after, new aptamer tags that have different properties or fluoresce in different colors (Broccoli, Corn, Red Broccoli, and Radish) were also introduced.
The Spinach aptamer was originally named as homage to the late Dr. Roger Tsien. Dr. Tsien named all of fluorescent proteins developed in his labs after fruits (e.g. mCherry, dTomato, mApple, mCitrine, etc.). Following this tradition, all aptamers derived from the Spinach™ technology are named after vegetables that best match their fluorescent colors.
Lucerna received a $1.5M phase II SBIR grant from the National Cancer Institute to develop a high-throughput drug screening platform to identify drugs that can correct a splicing event key to cancer's metabolic pathway. This platform uses the Spinach™ technology to generate fluorescent sensors that can detect endogenous splice isoforms in cells.
In 2017, Lucerna also successfully completed a R&D project for a top 5 pharma company to develop a custom splicing assay to identify novel splice modulating hits.
Our splicing drug discovery platform is high-throughput compatible, can target any endogenous spliced isoforms, and can detect hits that cause as small as 10% splicing changes.
Lucerna is always looking for ways to develop unique research and drug discovery tools to help solve urgent problems in the RNA world.
Current technologies in development include:
• Cell-based antiviral drug discovery platforms
• Enhanced fluorophores that allow single-molecule RNA imaging in live cells.
• Fluorescent sensors that report changes in RNA structures.
• Sensors that detect intracellular metabolic changes for drug discovery and for industrial biotechnology applications.
Proprietary dyes that turns on the fluorescence of the Spinach family of RNA aptamers.
High-throughput compatible assays with homogenous workflows and robust fluorescence readouts.
Custom fluorescent sensors that detect medically important RNAs with specificity and sensitivity.
lucerna technologies生物技术公司专注于开发和护理诊断和高通量药物发现点核酸传感器，此外，lucerna technologies还提供了新开发蛋白质组学研究的抗体。lucerna technologies跨学科的团队包括有机化学家，生物学家和表现在适体的研究和在生物分子分析经验的化学家。lucerna 致力为客户带来更好的产品与服务。
| lucerna公司DFHBI产品大量现货 | ||||||||||||||||||||||||||||||||||||||||||||
| 点击次数：812 发布时间：2017-06-01 | ||||||||||||||||||||||||||||||||||||||||||||
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品名：DFHBI 全名：3,5-difluoro-4-hydroxybenzylidene imidazolinone (DFHBI) 品牌：lucerna technologies 分子式：C12H10F2N2O2 分子量：252.22 CAS号：1241390-29-3 吸收与发射光谱
Absorption and fluorescence emission spectra of DFHBI in pH 7.4 buffer. 状态：冻干粉 保存：-20避光保存 2年 激活模式图：
应用于HEK23T细胞内RNA成像：
HEK293T cells were transfected with either 5S-control aptamer or 5S-SpinachTM plasmids and incubated with 20 µM DFHBI. Images are phase overlay with Hoechst-stained nuclei (blue) and SpinachTM fluorescence (green). 结构式：
3,5-difluoro-4-hydroxybenzylidene imidazolinone (DFHBI)
lucerna 货号400-1mg 410-1mg 大量现货，价格优惠 订货信息：
世界*实验材料供应商 LUCERNA TECHNOLOGIES 正式授权上海起发为其中国代理， LUCERNA TECHNOLOGIES 在一直是行业的标杆,一直为广大科研客户提供zui为的产品和服务,上海起发一直秉承为中国科研客户带来的产品，的服务，签约 LUCERNA TECHNOLOGIES 就是为了给广大科研客户带来更加完善的产品和服务,您的满意将是我们zui大的收获 LUCERNA TECHNOLOGIES 中国代理, LUCERNA TECHNOLOGIES 上海代理， LUCERNA TECHNOLOGIES 北京代理，LUCERNA TECHNOLOGIES 广东代理， LUCERNA TECHNOLOGIES 江苏代理LUCERNA TECHNOLOGIES 湖北代理,LUCERNA TECHNOLOGIES 天津,LUCERNA TECHNOLOGIES 黑龙江代理,LUCERNA TECHNOLOGIES 内蒙古代理,LUCERNA TECHNOLOGIES 吉林代理,LUCERNA TECHNOLOGIES 福建代理, LUCERNA TECHNOLOGIES 江苏代理,LUCERNA TECHNOLOGIES 浙江代理, LUCERNA TECHNOLOGIES 四川代理, Lucerna——活体胞内RNA示踪 绿色荧光蛋白的发现及其应用是生命科学研究史上一个重要的里程碑，使得细胞内不可见的重要蛋白无所遁形，进而明确其功能与调控机制。相较于蛋白质，近年在细胞内还揭示了一大类重要的分子——非编码RNA，这类特殊的RNA不编码蛋白，但是其数目远较编码RNA（mRNAs）多，包括microRNAs, Piwi-interacting RNAs, termini-associated RNAs等。目前对这一类RNA的研究方兴未艾，因技术上缺乏关键的研究工具对其细胞内定位于功能了解知之甚少。 胞内RNA成像技术可能是非编码RNA研究领域取得突破的关键，与绿色荧光蛋白相似，在目的RNA上标记荧光分子可以使RNA在荧光显微镜下呈现，明确其胞内定位，进而通过分子互作或药理学等技术了解其功能。然而目前的常规RNA成像技术难以在活细胞上应用，并且有效性存在很大问题。针对这一难题，来自威斯康星大学的研究人员成立了Lucerna公司，并研发了一种独特的基因编码系统用于活细胞内RNA的荧光标记。该系统利用一种可与绿色荧光蛋白媲美的RNA原件——Spinach（一种RNA与源于绿色荧光蛋白的荧光小分子结合体，可与目的RNA结合并发射荧光）使得在活细胞中实时成像目的RNA的动态机制。利用该系统，研究人员可望在RNA胞内转运，降解、毒性RNA聚焦以及其他RNA调控机制的研究中取得突破性进展。 Lucerna的研发团队拥有超过25年的RNA生物学研究、RNA适配体研发及荧光成像技术的相关经验，拥有多项RNA荧光适配体，并发表了大量高水平文献。相信凭借这些优势，Lucerna可为RNA研究人员提供的研究产品与解决方案。
我们公司zui大优势是强大的采购， 1：基本什么都能进口，血清，抗体，耗材，还有部分限制进口的， 2：货品全，现经营过700多个品牌，基本所有生物试剂耗材都可以进口，特别是冷偏的产品那就更有优势， 3：提供加急服务，一般1-2周到货，超过时限加急费全免 4：价格公道，绝大部分价格有优势，当然不能保证100%产品都是价格zui低,因为价格zui低意味着没有服务. 5：良好的信誉，大部分客户我们提供货到付款服务，客户包括清华，北大 交大 复旦，中山等100多所大学，ROCHE，阿斯利康，国药 ，fisher等500多家公司
6：我们还是Santa,Advanced Biotechnologies Inc, LUCERNA TECHNOLOGIES,bangs,BBInternational,crystalchem,dianova,FD Neurotechnologies,Inc. FormuMax Scientific,Inc, GePromegaridege, Glycotope Biotechnology GmbH; iduron,Innovative Research of America, Ludger, neuroprobe,LUCERNA TECHNOLOGIES, Polysciences,prospecbi, QA-BIO,quickzyme,FULLERLABS,INC,sterlitech；sysy,TriLink BioTechnologies,Inc；worthington-biochem,zyagen等几十家国外公司授权代理。 苏州蚂蚁淘生物科技有限公司 |
苏州蚂蚁淘生物科技有限公司是专业从事生物技术产品销售的高科技企业，是国内生物试剂、仪器、消耗品领域的知名企业之一。起发公司自成立以来，连续2年高速成长。公司的发展目标是建成专业从事生物技术产品销售、生产与开发的一流公司。
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