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Avexitide (Exendin (9-39)) 是特异竞争性的 glucagon-like peptide-1 (GLP-1) 受体拮抗剂。
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Avexitide Chemical Structure
CAS No. : 133514-43-9
| Description |
Avexitide (Exendin (9-39)) is a specific and competitive GLP-1 receptor antagonist. |
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| In Vitro |
GLP-1 plays a role in the control of fasting glucose. Avexitide (Exendin (9-39)), a truncated form of the GLP-1 agonist exendin-4, is a specific GLP-1 receptor antagonist[1]. |
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| In Vivo |
Continuous subcutaneous infusion of Avexitide (Exendin (9-39)) significantly raises fasting blood glucose levels in SUR-1 -/- mice without affecting glucose tolerance[2]. |
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| Clinical Trial |
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| Molecular Weight |
3369.76 |
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| Formula |
C₁₄₉H₂₃₄N₄₀O₄₇S |
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| CAS No. |
133514-43-9 |
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| Sequence |
Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 |
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| Sequence Shortening |
DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2 |
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| SMILES |
[DLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2] |
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| Shipping |
Room temperature in continental US; may vary elsewhere. |
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| Storage |
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| Solvent & Solubility |
In Vitro:
H2O : 50 mg/mL (14.84 mM; Need ultrasonic)
Preparing
Stock Solutions
*
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 |
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| References |
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苏州蚂蚁淘生物科技有限公司专注于为科研工作者提供CST，Abcam，Sigma，biorbyt，Abclonal，AbD Serotec，GeneTex，ENZO，ScienCell，BI，Swant，emfret，Biovision，Roche，Millipore，BD，Life，eBioscience，Thermo，Qiagen，Santa，Peprotech，R&D，ImmunoStar，GenStar，GeneCopoeia，Cusabio，Bioss，NeoBioscience
苏州蚂蚁淘生物科技有限公司专注于为科研工作者提供CST，Abcam，Sigma，biorbyt，Abclonal，AbD Serotec，GeneTex，ENZO，ScienCell，BI，Swant，emfret，Biovision，Roche，Millipore，BD，Life，eBioscience，Thermo，Qiagen，Santa，Peprotech，R&D，ImmunoStar，GenStar，GeneCopoeia，Cusabio，Bioss，NeoBioscience
塞拉菌素概述用途塞拉菌素CAS号:220119-17-5英文名称:Selamectin英文同义词:Stronghold;Selamectin;hypnocarpicacid;Revolution(antibiotic);AverMectinA1a,25-cyclohexyl-4'-O-de(2,6-dideoxy-3-O-Methyl-a-L-arabino-hexopyranosyl)-5-deMethoxy-25-de(1-Methylpropyl)-22,23-dihydro-5-(hydroxyiMino)-,(5Z)-;(5Z)-25-Cyclohexyl-4'-O-de(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-5-demethoxy-25Chemicalbook-de(1-methylpropyl)-22,23-dihydro-5-(hydroxyimino)-avermectinA1a中文名称:塞拉菌素中文同义词:塞拉菌素;司拉克丁;色拉霉素杂质;塞拉菌素/司拉克丁;SELAMECTIN塞拉菌素CBNumber:CB0947411分子式:C43H63NO11分子量:769.967MOLFile:220119-17-5.mol化学性质安全信息用途供应商102化学性质安全信息用途供应商102塞拉菌素化学性质沸点:917.0±65.0°C(Predicted)密度:1.35±0.1g/cm3(Predicted)储存条件:2-8°C酸度系数(pKa):10.34±0.70(Predicted)形态:neatInChIKey:AFJYYKSVHJGXSN-KAJWKRCWSA-N