ProductDescription
Amphiphilicblockcopolymerscomprisedofpoly(lacticacid-co-glycolicacid)andpoly(ethyleneglycol)areThermogellingmaterialswithbiodegradableblocks.Thethermogelformingbiodegradabledeliverysystemhastwomajorbenefit:1)First,thermogelationallowsfordeliveryoverthecourseofaperiodoftimeafterintroductionofwhatisinitiallyaliquid;2)Thematerialsafelybiodegradesawayonceitisnolongernecessarytolacticandglycolicacidsaswellasthewater-solublepoly(ethyleneglycol)block,whichatmolecularweightsbelow20KDaaresafelyeliminatedfromthebodybythekidneys.
Thethermogelationpropertiesofpoly(lacticacid-co-glycolicacid)-block-poly(ethyleneglycol)-block-poly(lacticacid-co-glycolicacid)(PLGA-PEG-PLGA)copolymershavebeenextensivelyusedinresearchforcontrolleddelivery.
