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ActivinAisahomodimerof14kDabeta-A.ActivinA,acytokinememberofthetransforminggrowthfactor-betasuperfamily,isexpressedlocallybythemesenchymalcomponentofthehemopoieticmicroenvironment.ItsexpressionisregulatedonthemRNAlevelbydifferentcytokines,andthebiologicalactivityoftheproteinistightlycontrolledbyseveralinhibitorymolecules.Inhibinsandactivinsaremembersofthetransforminggrowthfactorbetasuperfamilyandareknowntomodulatethegrowthanddifferentiationofseveralcelltypes.Inhibinsandactivinsinhibitandactivate,respectively,thesecretionoffollitropinbythepituitarygland.Inhibins/activinsareinvolvedinregulatinganumberofdiversefunctionssuchashypothalamicandpituitaryhormonesecretion,gonadalhormonesecretion,germcelldevelopmentandmaturation,erythroiddifferentiation,insulinsecretion,nervecellsurvival,embryonicaxialdevelopmentorbonegrowth,dependingontheirsubunitcomposition.Inhibinsappeartoopposethefunctionsofactivins.ThestandardproductusedinthiskitisrecombinantActivinA,whichiscomposedoftwosinglechainsof116aminoacidswiththemolecularmassof26KDa.