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Innovative Research/Human BDNF ELISA Kit/IRKTAH5020/1 Ea

ProductDescription

HumanBDNFELISAKit-1Kit(96Wells)
OurHumanBDNFELISAKitisasandwichELISAintendedforthequantitativedeterminationofhumanBDNFincellculturesupernates,serumandplasma(heparin,EDTA,citrate).

Brain-derivedneurotrophicfactor(BDNF)isaprosurvivalfactorinducedbycorticalneuronsthatisnecessaryforsurvivalofstriatalneuronsinthebrain.Itisasecretedproteinwiththemolecularweightof27.8kDa,consistingof247aminoacids.Itisknowntopromoteneuronalsurvivalanddifferentiation.BDNFsharessubstantialaminoacidsequenceidentitywithnervegrowthfactor(NGF).BDNFandneurotrophin-3(NT-3)aretworecentlyclonedneurotrophicfactorsthatarehomologoustoNGF.mRNAproductsoftheBDNFandNT-3genesaredetectedintheadulthumanbrain,suggestingthattheseproteinsareinvolvedinthemaintenanceoftheadultnervoussystem.BDNFandotherneurotrophinsarecriticallyinvolvedinlong-termpotentiation(LTP).BDNF-mediatedLTPisinducedpostsynaptically.BDNFhastrophiceffectsonSEROtonergic(5-HT)neuronsinthecentralnervoussystem.BDNFhasanessentialmaintenancefunctionintheregulationofanxiety-relatedbehaviorandinfoodintakethroughcentralmediatorsinboththebasalandfastedstate.Itplaysaroleintreatingbreathingdisorderssuchasrespiratoryinsufficiencyafterspinalinjury.ThematureformofBDNFisidenticalinallmammalsexamined,andthegeneencodinghumanBDNFtochromosome11,bandp13.

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