Innovative Research/Human CD93/C1qR ELISA Kit/IRKTAH5063/1 Ea

ProductDescription

HumanCD93/C1qRELISAKit-1Kit(96Wells)

OurHumanCD93/C1qRELISAKitisasandwichELISAintendedforthequantitativedeterminationofhumanCD93incellculturesupernates,serumandplasma(heparin,EDTA),salivaandurine.

CD93(ClusterofDifferentiation93)isaproteinthatinhumansisencodedbytheCD93gene.CD93belongstotheGroupXIVC-Typelectinfamilyandismappedto20p11.21.Theproteinencodedbythisgeneisacell-surfaceglycoproteinandtypeImembraneproteinthatwasoriginallyidentifiedasamyeloidcell-specificMarker.TheencodedproteinwasoncethoughttobeareceptorforC1q,butnowisthoughttoinsteadbeinvolvedinintercellularadhesionandintheclearanceofapoptoticcells.Theintracellularcytoplasmictailofthisproteinhasbeenfoundtointeractwithmoesin,aproteinknowntoplayaroleinlinkingtransmembraneproteinstothecytoskeletonandintheremodellingofthecytoskeleton.Ithasalsoshowedthatthisreceptorisapositivemarkerforallbonemarrow-repopulatingstemcellsbecauseitisexpressedonbothCD34-negativeandCD34-positivestemcellsfromumbilicalcordbloodandadultbonemarrow.Inaddition,highlypurifiedlineage-negativecellswiththeCD93proteinnotonlyhavebonemarrow-repopulatingcapacitybutalsocandifferentiateintohumanhepatocytesinvivo.

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