TIMP-2genisencodedby5exonsspanning83kbofgenomicDNA.TIMP-2is83kilobasepairs(kb)longwithexon-intronsplicingsiteslocatedinpreservedpositionsamongthethreemembersoftheTIMPfamily.Thegenefortissueinhibitorofmetalloproteinases-2islocalizedonhumanchromosomearm17q25.TIMP-2abrogatesangiogenicfactor-inducedendothelialcellproliferationinvitroandangiogenesisinvivoindependentofMMPinhibition.ThestandardproductusedinthiskitisrecombinanthumanTIMP-2withthemolecularmassof22Kdaand194aminoacid.